海南医学院学报2017，Vol.23Issue(7)：904-906,910,4.DOI:10.13210/j.cnki.jhmu.20170111.001
灯盏花素联合奥曲肽对重症急性胰腺炎患者炎症因子及血管活性物质的影响
Effect of breviscapine combined with octreotide on the inflammatory reaction and vasoactive substances in patients with severe acute pancreatitis
摘要
Abstract
Objective: To explore the effect of breviscapine in combined with octreotide on the inflammatory reaction and vasoactive substances in patients with severe acute pancreatitis (SAP).Methods: A total of 72 patients with SAP who were admitted in our hospital from January, 2014 to November, 2016 were included in the study and randomized into the observation group and the control group.The patients in the two groups were given gastrointestinal decompression, water deprivation, fasting, infection prevention, and acid-base imbalance and electrolyte disturbance correcting.The patients in the control group were given micropump intravenous injection of octreotide (0.6 mg) and normal saline (48 mL), 1 time/12 h.On this basis, the patients in the observation group were given intravenous injection of breviscapine (20 mg) and 5% glucose (250 mL), 1 time/d.After 10d-treatment, the efficacy was evaluated.The morning fasting peripheral venous blood before and after treatment in the two groups was collected.ELISA was used to detect CRP, TNF-α, IL-8, IL-15, NO, and vWF.RIA was used to detect the plasma TXB2, 6-keto-PGF1α, and ET concentration.The full automatic blood rheometer was used to detect HCT, EAI, whole blood low shear viscosity, whose blood high shear viscosity, and plasma viscosity.Results: HCT, EAI, whole blood low shear viscosity, whose blood high shear viscosity, and plasma viscosity after treatment in the observation group were significantly lower than those in the control group (P<0.05).The serum CRP, IL-8, IL-15, and TNF-α levels after treatment in the observation group were significantly lower than those in the control group (P<0.05).The plasma ET, TXB2, and vWF levels after treatment in the observation group were significantly lower than those in the control group (P<0.05), while 6-keto-PGF1α and NO levels were significantly higher than those in the control group (P<0.05).Conclusions: Breviscapine in combined with octreotide can effectively inhibit the inflammatory reaction in patients with SAP, improve the vascular endothelial function, hemodynamics, and microcirculation disturbance, and promote the recovery.关键词
灯盏花素/奥曲肽/重症急性胰腺炎/炎症反应/血管内皮功能Key words
Breviscapine/Octreotide/SAP/Inflammatory reaction/Vascular endothelial function分类
医药卫生引用本文复制引用
娄继哲,白睿..灯盏花素联合奥曲肽对重症急性胰腺炎患者炎症因子及血管活性物质的影响[J].海南医学院学报,2017,23(7):904-906,910,4.基金项目
河北省科学技术成果获奖项目(20120150) （20120150）
The study was supported by the Scientific and Technological Achievement Awards Project of Hebei Province with the number of 20120150. （）
