海南医学院学报2017，Vol.23Issue(7)：911-913,917,4.DOI:10.13210/j.cnki.jhmu.20170406.007
尼可地尔对糖尿病患者PCI术后心肌组织血流灌注及心肌细胞损伤的影响
Effect of nicorandil on the myocardial tissue perfusion and myocardial cell injury in patients with diabetes after PCI
摘要
Abstract
Objective: To study the effect of nicorandil on the myocardial tissue perfusion and myocardial cell damage in patients with diabetes after PCI.Methods: 68 patients with coronary heart disease and type 2 diabetes mellitus who received PCI in our hospital between May 2011 and September 2015 were collected and then divided into observation group and control group (n=34) according to the single-blind randomized control method.Control group of patients received PCI alone, and the observation group of patients received nicorandil therapy after PCI.After treatment, real-time myocardial ultrasound contrast was used to evaluate the myocardial perfusion of two groups of patients;blood biochemical analyzer was used to detect the contents of peripheral blood myocardial enzyme spectrum indexes;the ELISA method was used to detect the contents of serum oxidative stress indicators;RIA method was used to detect the contents of serum apoptosis molecules.Results: After treatment, the myocardial tissue perfusion parameters A, β and A×β levels of observation group were significantly higher than those of control group (P<0.05);peripheral blood myocardial enzyme spectrum indexes CK, LDH, cTnⅠ and GOT contents of observation group were significantly lower than those of control group (P<0.05);serum VitE and VitC contents of observation group were significantly higher than those of control group while MDA, AOPPs, sFas and sFasL contents were lower than those of control group (P<0.05).Conclusions: Adjuvant nicorandil therapy can improve the myocardial perfusion and reduce the myocardial cell injury in patients with coronary heart disease and diabetes mellitus after PCI.关键词
糖尿病/经皮冠状动脉介入/尼可地尔/血流灌注/心肌细胞损伤Key words
Diabetes mellitus/Percutaneous coronary intervention/Nicorandil/Blood perfusion/Myocardial cell injury分类
医药卫生引用本文复制引用
任雪丽,沈桂冬,刘杰,谭仕芸,金鑫,陈海波,叶靖,邓丽丽,吴飞妮..尼可地尔对糖尿病患者PCI术后心肌组织血流灌注及心肌细胞损伤的影响[J].海南医学院学报,2017,23(7):911-913,917,4.基金项目
陕西省社会发展科技攻关项目(2015SF022) （2015SF022）
It was supported by Social Development Science and Technology Research Project of Shaanxi Province (No.2015SF022). （No.2015SF022）
