海南医学院学报2017，Vol.23Issue(7)：954-957,4.DOI:10.13210/j.cnki.jhmu.20170113.009
法舒地尔注射液辅助手术治疗脑外伤对应激激素及炎症因子的影响
Effects of fasudil injection on stress hormone and inflammatory factors in the treatment of traumatic brain injury
摘要
Abstract
Objective: To investigate the effect of fasudil injection on stress hormone and inflammatory factors in the treatment of traumatic brain injury.Methods: A total of 120 cases of traumatic brain injury were divided into control group and observation group according to the odd with 60 cases in each group.The control group was given conventional therapy including hemostasis, intracranial pressure control, neurotrophic drugs and anti-infection , the observation group was given fasudil injection on the basis of routine treatment, compare the serum stress hormones ACTH, NE, Cor and inflammatory factors IL-1, IL-6, TNF-α levels between two groups before treatment (T0) and after treatment 3 d (T1) and 7 d (T2).Results: The ACTH, NE, Cor and IL-1, IL-6, TNF-α levels in T0 serum were not significantly different between the two groups (all P>0.05).As the treatment progressed, serum ACTH, NE, Cor levels of T1 and T2 were lower than T0 in both groups , when T2 was lower than T1, which showed a gradual downward trend,two groups of T1 serum IL-1, IL-6 and TNF-α levels were higher than T0, when T2 was lower than T1 and T0, it showed increased first and then decreased, the difference was statistically significant (P<0.05);Observation group T1 serum ACTH, NE, Cor and IL-1, IL-6 and TNF-α levels were (67.2±9.8) pg/mL, (685.71±181.83) pg/mL, (251.65±50.35) ng/mL, (6276.38±52.05) pg/mL, (231.34±29.02) pg/mL, (92.21±15.25) ng/mL, respectively, significantly lower than those in T1 of the control group;Observation group T2 serum ACTH, NE, Cor and IL-1, IL-6 and TNF-α levels were (55.16+8.05) pg/mL, (426.72+150.14) pg/mL ,(202.36+39.18) ng/mL, (108.37+38.38) pg/mL, (111.36+21.15) pg/mL, (40.72+13.42) ng/mL respectively, significantly lower than those in T2 of the control group, the differences were statistically significant (P<0.05).Conclusions: Fasudil injection can relieve the stress reaction and control the level of inflammatory factors in patients with brain trauma.关键词
法舒地尔/脑外伤/应激激素/炎症因子Key words
Fasudil/Brain trauma/Stress hormones/Inflammatory factors分类
医药卫生引用本文复制引用
魏小川,熊学辉,罗杰..法舒地尔注射液辅助手术治疗脑外伤对应激激素及炎症因子的影响[J].海南医学院学报,2017,23(7):954-957,4.基金项目
湖北省科技计划项目(2015DD2139) （2015DD2139）
It was supported by Science and Technology Planning Project of Hubei Province with the number of 2015DD2139. （）
