海南医学院学报2017，Vol.23Issue(7)：969-972,4.DOI:10.13210/j.cnki.jhmu.20170113.015
阿奇霉素配伍脂溶性维生素对支原体肺炎患儿血清炎症因子、趋化因子及肺功能的影响
Effect of azithromycin combined with fat-soluble vitamin on serum inflammatory cytokines and chemokines as well as lung function in children with Mycoplasma pneumoniae
摘要
Abstract
Objective: To study the effect of azithromycin combined with fat-soluble vitamin on serum inflammatory cytokines and chemokines as well as lung function in children with Mycoplasma pneumoniae.Methods: A total of 56 children with mycoplasma pneumonia admitted in our hospital between May 2012 and May 2016 were collected, the treatment methods and laboratory test results were retrospectively analyzed, and then they were divided into the control group (n=26) who received azithromycin treatment alone and the observation group (n=30) who received fat-soluble vitamin combined with azithromycin treatment.Before treatment and after 1 week of treatment, enzyme-linked immunosorbent assay (ELISA) was used to detect the serum levels of inflammatory cytokines and chemokines;lung function monitor for children was used to detect lung function index levels.Results: Before treatment, differences in serum inflammation index and chemokine contents as well as lung function indexes were not statistically significant between two groups of patients (P>0.05).After treatment, serum inflammation indexes IL-4 and IL-13 contents of observation group were lower than those of control group while IL-10 and IL-12 contents were higher than those of control group (P<0.05);serum chemokines MCP-4, MDC and CysLTs contents of observation group were lower than those of control group (P<0.05);lung function indexes V-T, FEV1, PEF and MMEF25%-75% levels of observation group were higher than those of control group (P<0.05).Conclusions: Fat-soluble vitamin combined with azithromycin can reduce the systemic inflammatory response and optimize the lung function in children with mycoplasma pneumoniae infection.关键词
小儿肺炎支原体感染/脂溶性维生素/阿奇霉素/炎症反应/肺功能Key words
Mycoplasma pneumoniae infection/Children/Fat-soluble vitamin/Azithromycin/Inflammatory response/Lung function分类
医药卫生引用本文复制引用
杨明光,德勤..阿奇霉素配伍脂溶性维生素对支原体肺炎患儿血清炎症因子、趋化因子及肺功能的影响[J].海南医学院学报,2017,23(7):969-972,4.基金项目
四川省科技计划项目(2014FZ0036) （2014FZ0036）
It was supported by Sichuan Science and Technology Project with the number of 2014FZ0036. （）
