海南医学院学报2017，Vol.23Issue(7)：994-996,1000,4.DOI:10.13210/j.cnki.jhmu.20170113.002
射频辅助肝切除术治疗原发性肝癌对癌细胞凋亡及正常肝脏组织损伤的影响
Effect of radiofrequency-assisted hepatectomy treatment of primary liver cancer on cancer cell apoptosis and normal liver tissue damage
摘要
Abstract
Objective: To study the effect of radiofrequency-assisted hepatectomy treatment of primary liver cancer on cancer cell apoptosis and normal liver tissue damage.Methods: A total of 50 patients with primary liver cancer who received surgery in our hospital between May 2011 and August 2015 were collected, their operation methods and test results were reviewed, and then they were divided into the control group (n=30) who received hepatectomy treatment alone and the observation group (n=20) who received radiofrequency-assisted hepatectomy treatment.Intraoperative tumor tissue was collected to detect the proliferation and apoptosis gene mRNA expression by fluorescent quantitative PCR;3 d after operation, serum was collected to detect serum liver enzyme index levels by immune scatter turbidimetry.Results: IFITM3, NCX1, CXCR2, Cep55 and Bcl-2 mRNA expression in liver cancer tissue of observation group were lower than those of control group while Caspase-3 and Cyt-C mRNA expression were higher than those of control group (P<0.05);3 d after operation, serum liver enzyme indexes ALT, AKP and GGT levels of observation group were not significantly different from those of control group (P>0.05).Conclusions: Radiofrequency-assisted hepatectomy can effectively induce liver cancer cell apoptosis without increasing the normal liver tissue damage.关键词
原发性肝癌/肝切除术/射频/凋亡/肝功能Key words
Primary liver cancer/Hepatectomy/Radiofrequency/Apoptosis/Liver function分类
医药卫生引用本文复制引用
孟钰..射频辅助肝切除术治疗原发性肝癌对癌细胞凋亡及正常肝脏组织损伤的影响[J].海南医学院学报,2017,23(7):994-996,1000,4.基金项目
河南省教育厅自然科学基础研究计划(2013A280045) （2013A280045）
It was supported by Basic Science Research Program of Henan Provincial Department of Education with the number of 2013A280045. （）
