解放军医药杂志2017，Vol.29Issue(3)：15-17,3.DOI:10.3969/j.issn.2095-140X.2017.03.004
CD34 +自体干细胞移植联合DC-CIK细胞免疫治疗复发难治性淋巴瘤疗效观察
Effect Observation of CD34 + Autologous Stem Cell Transplantation Combined with DC-CIK Cell Immunotherapy in Treatment of Patients with Recurrent and Refractory Lymphoma
摘要
Abstract
Objective To study clinical efficacy and safety of CD34 + autologous hematopoietic stem cell transplantation combined with dendritic cells and cytokine-induced killer (DC-CIK) cells immunotherapy in treatment of patients with recurrent and refiractory lymphoma.Methods A total of 48 patients with recurrent and refractory lymphoma during January 2011 and Mav 2014 were divided into control group and observation group according to clinical treatment methods (n =24 for each group).Control group was added with CD34 + autologous stem cell transplantation on the basis of routine treatment for lymphoma,and observation group was added with DC-CIK cells immunotherapy on the basis of treatment for control group.Clinical efficacy,adverse reaction and prognosis were evaluated and compared after treatment in two groups.Results The total effective rate in observation group was significantly higher than that in control group (P ＜0.05).There was no significant difference in incidence rate of adverse reactions between the two groups (P ＞0.05).The average survival times and median survival times were 20 months and 18 months in observation group and 16 months and 14 months in control group respectively.The overall survival rate in observation group was significantly higher than that in control group (P ＜ 0.05).Conclusion CD34 + autologous hematopoietic stem cell transplantation combined with DC-CIK cells immunotherapy in treatment of patients with recurrent and refractory lymphoma can achieve better clinical efficacy,high safety,less adverse reaction and acceptable prognosis.关键词
复发/淋巴瘤/移植,自体/树突细胞/细胞因子诱导杀伤细胞/免疫疗法Key words
Recurrence/Lymphoma/Transplantation, autologous/Dendritic cells/Cytokine-induced killer cells/Immunotherapy分类
医药卫生引用本文复制引用
范方毅,邓锐,苏毅..CD34 +自体干细胞移植联合DC-CIK细胞免疫治疗复发难治性淋巴瘤疗效观察[J].解放军医药杂志,2017,29(3):15-17,3.基金项目
四川省卫生厅科研项目(120565) （120565）
