解放军医药杂志2017，Vol.29Issue(3)：31-34,4.DOI:10.3969/j.issn.2095-140X.2017.03.008
原发性肝癌患者血清可溶性细胞间黏附分子-1的水平及其与肝纤维化的关系
Level of sICAM-1 and Its Relationship with Liver Fibrosis in Patients with PHC
摘要
Abstract
Objective To investigate level of soluble intercellular adhesion molecule-1 (sICAM-1) and its relationship with liver fibrosis in patients with primary hepatic carcinoma (PHC).Methods A total of 40 PHC patients undergoing surgery during January 2014 and February 2016 were selected as PHC group,and other 40 patients with benign liver disease and 40 normal people were chosen as benign fiver disease group and normal group.Enzyme linked immunosorbent assay (ELISA) was used to detect levels of sICAM-1 and liver fibrosis markers such as procollagen Ⅲ (PC Ⅲ),type Ⅳ collagen (Ⅳ-C),laminin (LN) and hyaluronic acid (HA) in three groups,and correlation between serum sICAM-1 level and liver fibrosis markers was compared.Results Serum sICAM-1,LN,PC Ⅲ,HA and Ⅳ-C levels in PHC group were significantly higher than those in benign liver disease and normal groups (P ＜ 0.05),and the sICAM-1 level in benign liver disease group was significantly higher than that in normal group (P ＜ 0.05).Serum sICAM-1 level had positive correlation with LN,PC Ⅲ,HA and Ⅳ-C levels (r =0.575,0.679,0.541 and 0.577,P ＜ 0.05).Conclusion Detection of serum sICAM-1 can reflect the occurrence,development and injury degree of hepatocyte in PHC patients,and it has positive correlation with liver fibrosis markers,and therefore it has important significance in early diagnosis and treatment of PHC.关键词
肝肿瘤/可溶性细胞间黏附分子-1/肝纤维化Key words
Liver neoplasms/Soluble intercellular adhesion molecule-1/Liver fibrosis分类
医药卫生引用本文复制引用
张先俊,徐莉芳,何忠良..原发性肝癌患者血清可溶性细胞间黏附分子-1的水平及其与肝纤维化的关系[J].解放军医药杂志,2017,29(3):31-34,4.基金项目
潜江市中心医院科研项目(qyzz2014004) （qyzz2014004）
