河北医学2017，Vol.23Issue(3)：356-359,4.DOI:10.3969/j.issn.1006-6233.2017.03.002
聚乙二醇干扰素α-2a联合利巴韦林治疗慢性丙型肝炎的疗效评价
Antiviral Effect in Patients with Chronic Hepatitis C Treatedwith Peg-interferon α-2a Combined with Ribavirin
摘要
Abstract
Objective:To observe the pathological changes of chronic hepatitis C after the treatment of peg-interferon α-2a combined with ribavirin.Methods:40 patients with chronic hepatitis C visited our hospital from October 2014 to October 2015 as the research object, were randomly divided into two groups, 20 cases in each group.Observation group was treated with peg interferon α-2a and ribavirin, the control group was given general hepatoprotective treatment, The levels of ALT, HCVRNA and the pathological tissue of the two groups were compared.Results:After treatment, the observation group ALT recovery rate was 80%, there's no significant difference with the control group (P>0.05);the observation group HCVRNA negative rate was 90%, compared with the control group were significantly higher (P<0.05);liver inflammation and fibrosis of the observation group was significantly lower than before, and significantly lower than the control group (P<0.05).Conclusion:Antiviral treatment can significantly reduce the degree of liver inflammatory activity and fibrosis.It is of great significance to evaluate the effect of antiviral therapy from the pathological point.关键词
丙型肝炎病毒/慢性肝炎/组织病理学/聚乙二醇干扰素α-2aKey words
Hepatitis C virus/Chronic hepatitis/Histopathology/Peg interferon α-2a引用本文复制引用
姚维敏,郭健文,陈焰..聚乙二醇干扰素α-2a联合利巴韦林治疗慢性丙型肝炎的疗效评价[J].河北医学,2017,23(3):356-359,4.基金项目
广东省佛山市医学类科技攻关项目,(编号:2014AB000262) （编号:2014AB000262）
