河北医学2017，Vol.23Issue(4)：580-584,5.DOI:10.3969/j.issn.1006-6233.2017.04.015
促红细胞生成素联合甲泼尼龙对急性间质性肾炎患者的疗效及IL-6 TNF-α水平的影响
Effect and Influence of Erythropoietin and Methylprednisolone on Acute Interstitial Nephritis patients and IL-6 TNF-alpha
摘要
Abstract
Objective:To study effect and its influence of interleukin-6 (IL-6), tumor necrosis factor alpha (TNF-α) of erythropoietin and methylprednisolone in the treatment of patients with acute interstitial nephritis.Methods: 96 patients with AIN who were treated in our hospital from January 2015 to December 2016 were selected as study object.The patients were divided into observation group and control group with 48 cases in each group.The two groups were discontinued may lead to AIN drugs, and corrected the acidosis, while maintained the body of water electrolyte balance.The control group was given methylprednisolone, modified Chengponisong oral in the treatment of 3d, the observation group was another given EPO for treatment.Two groups were treated for 1 month then compared the comparison of efficacy, clinical indicators, adverse reactions, and the two groups before treatment and after treatment of IL-6 and TNF-α level.Results: The effective rate of the observation group was 43.75%, and the total effective rate was about 97.92%, respectively compared with the control group of 16.67% and 83.33% were significantly higher, the difference was statistically significant (P < 0.05).In the observation group, the time of oliguria, the time of polyuria, the time of disappearance of hematuria and proteinuria, and the recovery of renal function to normal were significantly less than those in the control group, the difference was statistically significant (P < 0.05).After treatment, the levels of IL-6 and TNF-α in two groups were significantly lower than those before treatment, and the observation group was lower than the control group, the difference was statistically significant (P < 0.05).The total incidence of adverse reactions in the observation group was 10.42%, compared with the control group of 12.50%, the difference was not statistically significant (P > 0.05).Conclusion: The application of EPO and methylprednisolone on the curative effect of treatment of AIN patients with better implementation of the high safety, reduce the release of inflammatory cytokines and anti-inflammatory action.It is worthy of application and popularization.关键词
促红细胞生成素/甲泼尼龙/急性间质性肾炎/IL-6/TNF-α水平Key words
Erythropoietin/Methylprednisolone/Acute interstitial nephritis/Curative effect/IL-6/TNF-α引用本文复制引用
刘绥军,张芙萍..促红细胞生成素联合甲泼尼龙对急性间质性肾炎患者的疗效及IL-6 TNF-α水平的影响[J].河北医学,2017,23(4):580-584,5.基金项目
陕西省卫生厅科研基金项目,(编号:2015J012) （编号:2015J012）
