摘要
Abstract
Objective To explore the clinical characteristics,diagnosis and MRI features of primary progressive freezing gait(PPFG).Methods The clinical data of six patients with suspected PPFG who had been followed up for 2 to 4 years were analyzed in detail.Results The age of included patients was(78.5±1.2)years.Recurrent freezing gait was the prominent symptom and worsened year by year.Other positive signs of non-motor symptoms,such as anxiety,depression,sweating,constipation,pollakisuria and somnolence,were involved in disease process.With accordant manifestations,brain MRI showed different degrees of demyelinating in the white matter of ventricle and encephalanalosis.Patients did not respond to large doses of compound levodopa.However,some combination therapy with selegiline,DA agonists,amantadine or droxidopa was effective.Conclusion The clinical manifestations of 6 patients conform to diagnostic criteria of PPFG,but manifestations with slight non-motor symptoms are out of accord with other reports.The imaging of MRI has similar performance,which may improve the study of disease etiology.However,to make a final diagnosis of PPFG,long-term follow-up observation or pathological examination would be necessary.关键词
冻结步态/磁共振/非运动症状Key words
Freezing gait/MRI/Non-motor syndrome分类
医药卫生
