中国实用神经疾病杂志2017，Vol.20Issue(8)：12-14,3.
高分辨率磁共振评价阿托伐他汀钙对颈动脉硬化不稳定斑块的影响
Effect of atorvastatin calcium therapy for unstable carotid plaque evaluated by high resolution nuclear magnetic resonance imaging
摘要
Abstract
Objective To evaluate the effects of 20 mg or 10 mg atorvastatin on the unstable carotid atherosclerosis plaque by high resolution nuclear magnetic resonance imaging(MRI).Methods Totally 100 inpatient cases with unstable carotid plaque from March 2013 to May 2016 were randomly divided into high-dose group and low-dose group,which received 20 mg and 10 mg atorvastatin respectively.High resolution nuclear MRI before and one year after treatment was applied and levels of plasma lipids and C-reactive protein were detected to assess the quantity and average thickness of unstable plaque.Results One year after treatment,blood lipid levels such as total cholesterol,triglycerides and low-density lipoprotein cholesterin were decreased and high-density lipoprotein cholesterol level was increased.High resolution nuclear MRI showed that the quantity and average thickness of unstable plaque were dramatically reduced compared with those before treatment(P<0.05).Conclusion Atorvastatin calcium can decrease the blood lipid and C-reactive protein levels and has an effect on anti-atherosclerosis.关键词
高分辨磁共振/阿托伐他汀钙/颈动脉粥样硬化/不稳定斑块Key words
High resolution nuclear magnetic resonance/Atorvastatin calcium/Carotid artery atherosclerosis/Unstable plaque分类
医药卫生引用本文复制引用
王龙安,韩涵,崔维..高分辨率磁共振评价阿托伐他汀钙对颈动脉硬化不稳定斑块的影响[J].中国实用神经疾病杂志,2017,20(8):12-14,3.基金项目
河南省重点科技攻关项目(编号:112102310234) （编号:112102310234）
