华侨大学学报（自然科学版）2017，Vol.38Issue(2)：175-179,5.DOI:10.11830/ISSN.1000-5013.201702008
DTPA胃漂浮囊心缓释片制备与体外释放性能
Preparation and In Vitro Release of DTPA Intragastric Floating Sustained-Release and Capsule-Heart Tablets
摘要
Abstract
Diethylene triamine pentaacetic acid (DTPA) intragastric floating sustained-release and capsule-heart tablets were prepared by pressing the powder directly, and the in vitro floatation, release characteristics and release mechanism were studied.Results indicated that DTPA intragastric floating sustained-release and capsule-heart tablets could float immediately in the simulated gastric fluid, floating up to 24 hours continuously, and the in vitro drug release with Korsmeyer-Peppas (Tlag) model fitting was the best.At the same time, it was proved that the drug release was controlled by diffusion and matrix erosion together using Harland equation for validation.In conclusion, intragastric floating sustained-release and capsule-heart tablets have the advantages of short floating lag time, long floating duration and good sustained-release effect.In addition, the floating characteristics were not affected by the excipients and the preparation technologies.关键词
二乙基三胺五乙酸/胃漂浮囊心缓释片/漂浮性能/释药机理Key words
diethylene triamine pentaacetic acid/intragastric floating sustained-release and capsule-heart tablets/floating characteristics/release mechanism分类
医药卫生引用本文复制引用
王立强,卢迅,应侠,陈锐..DTPA胃漂浮囊心缓释片制备与体外释放性能[J].华侨大学学报（自然科学版）,2017,38(2):175-179,5.基金项目
福建省自然科学基金资助项目(2015J01342) （2015J01342）
