江苏大学学报（医学版）2017，Vol.27Issue(2)：146-149,4.DOI:10.13312/j.issn.1671-7783.y160306
探究性眼球轨迹运动对轻度认知功能障碍和早期阿尔茨海默病的诊断价值
Value of exploratory eye movement examination in the diagnosis ofmild cognitive impairment and early-stage Alzheimer disease
摘要
Abstract
Objective:To study the value of exploratory eye movement examination in the diagnosis of mild cognitive impairment or early-stage Alzheimer disease(early-stage AD).Methods:The subjects were divided into three groups:individuals with mild cognitive impairment(MCI),patients with early-stage AD,and normal controls,with 30 cases in each group.All the subjects were evaluated with the Montreal Cognitive Assessment(MoCA) and underwent exploratory eye movement examination.The measures of exploratory eye movements include number of eye fixation(NEF),responsive search score(RSS) and discriminant analysis value(D value).The measures of exploratory eye movements were compared among three groups,and the associations between MoCA scores and the eye movement measures were examined.Results:There were statistically significant differences in NEF,RSS,and D value among the three groups(P<0.01).MoCA scores were positively correlated with NEF and RSS(P<0.01) and were negatively correlated with D value(P<0.01) in MCI group and early-stage AD group.Conclusion:Exploratory eye movement examination may be used in distinguishing-individuals with MCI or early-stage AD,and the measures of exploratory eye movement may reflect the severity of cognitive impairment.关键词
眼动检查/轻度认知功能障碍/阿尔茨海默病/蒙特利尔认知评估量表/简易精神状态量表Key words
exploratory eye movement examination/mild cognitive impairment/Alzheimer disease/Montreal Cognitive Assessment/Mini-Mental State Examination分类
医药卫生引用本文复制引用
顾君,李国海,刘晓伟,徐清,朱红梅..探究性眼球轨迹运动对轻度认知功能障碍和早期阿尔茨海默病的诊断价值[J].江苏大学学报（医学版）,2017,27(2):146-149,4.基金项目
南京医科大学科技发展基金资助项目(2014NJMU113) （2014NJMU113）
