实用临床医药杂志2017，Vol.21Issue(5)：11-14,4.DOI:10.7619/jcmp.201705003
Claudin-4在炎症性肠病小鼠结肠黏膜中的表达及意义
Expression and significance of claudin-4 in colon mucosa of mice with inflammatory bowel disease
摘要
Abstract
Objective To observe the claudin-4 expression in inflammatory bowel disease mice models which induced by dextran sulfate sodium (DSS).Methods Fourteen mice were established inflammatory bowel disease models induced by 7-day administration of 2.5％ DSS in water.The other six mice were fed with water only as control group.Pathological changes in colon mucosa were observed on the eighth day.Immunohistochemistry and western blot were used to measure the protein expression of claudin-4 in colon mucosa.Results IBD model was successfully established according to weight and pathological changes.The claudin-4 expression in the model group mice decreased significantly compared with control group and the difference was statistically significant(P ＜0.05).Conclusion Claudin-4 expression level decreased in colon mucosa of IBD mice.The change of the claudin-4 expression may play an important role in IBD development and progression.关键词
claudin-4/葡聚糖硫酸钠/炎症性肠病Key words
claudin-4/Dextran sulfate sodium/inflammatory bowel disease分类
医药卫生引用本文复制引用
衡广蓉,丁岩冰,路国涛..Claudin-4在炎症性肠病小鼠结肠黏膜中的表达及意义[J].实用临床医药杂志,2017,21(5):11-14,4.基金项目
江苏省扬州市社会发展项目(YZ2011088) （YZ2011088）
