解放军医学院学报2017，Vol.38Issue(4)：313-316,4.DOI:10.3969/j.issn.2095-5227.2017.04.006
早中孕期血清学筛查唐氏综合征策略比较
First or/and second trimester maternal serum screening for Down's syndrome: A comparative study
摘要
Abstract
Objective To study the value of screening for Down's Syndrome in the first or/and second trimesters of pregnancy and explore the optimal screening strategy for Down's syndrome. Methods Total of 110 pregnant women were enrolled in this study from March 2014 to November 2015 received measurement of fetal nuchal translucency (NT), and detection of the concentration of maternal serum markers in first-trimester and second-trimester. The high risk rate was assessed according to screening strategies of the first-trimester one-stop screening, the second-trimester triple serum screening and the first-trimester combined with the second-trimester screening, respectively. Results The total high risk rates were 10.9%(12/110), 9.8%(9/92) and 5.4%(5/92) in the first-trimester one-stop screening, second-trimester triple serum screening, and the combined test of the first-trimester and second-trimester screening, respectively. The significant differences were observed between the combined test and the first-trimester one-stop screening or the second-trimester triple serum screening test (χ2=29.54, P < 0.05; χ2=20.65, P < 0.05). Conclusion The high risk rate decreased in the combined test of the first-trimester and the second-trimester triple serum screening, which is of great value in screening for Down's syndrome.关键词
早孕期/中孕期/血清学/唐氏综合征Key words
first-trimester/second-trimester/serology/Down's syndrome分类
医药卫生引用本文复制引用
姜淑芳,付玉荣,马莹,徐虹,李江华,毛仑,汪龙霞,高志英,卢彦平..早中孕期血清学筛查唐氏综合征策略比较[J].解放军医学院学报,2017,38(4):313-316,4.基金项目
解放军总医院临床科研扶持基金(2013FC-TSYS-1003) （2013FC-TSYS-1003）
