检验医学与临床2017，Vol.14Issue(8)：1071-1073,3.DOI:10.3969/j.issn.1672-9455.2017.08.010
乳杆菌活菌胶囊在宫颈癌同步放化疗中对HPV抑制作用的研究
Study on inhibition role of lactobacillus capsules against HPV in concurrent chemoradiotherapy of cervical cancer
摘要
Abstract
Objective To study the inhibition role of lactobacillus capsules against HPV in concurrent chemoradiotherapy of cervical cancer.Methods A total of 86 cases of HPV-positive non-surgical indications advanced cervical cancer(Ⅱb-Ⅳa) diagnosed by the pathological gold standard in Chongqing Three Gorges Central Hospital were selected and divided into the observation group and control group,43 cases in each group.The observation group was given the concurrent chemoradiotherapy+lactobacillus capsules treatment,while the control group was given the simple concurrent chemoradiotherapy.Then the HPV negative conversion rate and clinical efficacy in the two groups were statistically analyzed.Results The HPV negative conversion rate in the observation group was 90.7%(39/43),which was significantly higher than 55.8%(24/43) in the control group,the difference was statistically significant(P<0.05),the HPV continued positive rate in the observation group was 9.3%(4/43),which was significantly lower than 44.2%(19/43) in the control group,the difference was statistically significant(P<0.05);the total effective rate in the observation group was 93.0%(40/43),which was significantly higher than 65.1%(28/43) in the control group,the difference was statistically significant(P<0.05).Conclusion Lactobacillus capsules can effectively inhibit HPV in the concurrent chemoradiotherapy of cervical cancer,so is worthy of promotion in clinic.关键词
乳杆菌活菌胶囊/宫颈癌/同步放化疗/人乳头状瘤病毒/抑制作用Key words
lactobacillus capsules/cervical cancer/concurrent chemoradiotherapy/HPV/inhibition引用本文复制引用
张卜娟,饶辉,刘学芬,陈晓品,熊德明,刘华文,赵昕,李学芹,莫小飞,范运秀..乳杆菌活菌胶囊在宫颈癌同步放化疗中对HPV抑制作用的研究[J].检验医学与临床,2017,14(8):1071-1073,3.基金项目
重庆市基础与前沿研究资助项目(cstc2014jcyjA10049). （cstc2014jcyjA10049）
