临床口腔医学杂志2017，Vol.33Issue(4)：203-207,5.DOI:10.3969/j.issn.1003-1634.2017.04.004
软骨分化间充质干细胞对颞下颌关节炎软骨修复的影响
Effect of chondrogenic differentiation of autologous mesenchymal stem cells on cartilage repair in osteoarthritis of temporomandibular joint in vitro
摘要
Abstract
Objective:This study investigated the effects of chondrogenic differentiated mesenchymal stem cells(MSCs)on cartilage in temporomandibular joint osteoarthritis(TMJOA) in vitro.Methods:Four weeks after induction of osteoarthritis(OA),the joints received hylartin solution,non-chondrogenic MSCs or in vitro chondrogenic differentiated MSCs.The changes in cartilage were evaluated by histology,reverse transcription polymerase chain reaction.Results:The differentiated MSC-treated group had better histology than the MSC-treated group at 4 and 12 weeks,but with no difference at 24 weeks.Transplanted cells were observed at cartilage and the synovial membrane lining at 4 weeks.Conclusion:Intraarticular injection of MSCs could delay the progression of TMJOA,and in vitro chondrogenic induction of MSCs could enhance the therapeutic effects.关键词
骨髓间充质干细胞/软骨细胞分化/颞下颌关节/骨性关节炎/软骨Key words
Mesenchymal stem cells/Chondrogenic differentiation/Temporomandibular joint/Osteoarthritis/Cartilage分类
生物科学引用本文复制引用
王鹏,陈瞰,任笑春,叶斌,李运峰,祝颂松..软骨分化间充质干细胞对颞下颌关节炎软骨修复的影响[J].临床口腔医学杂志,2017,33(4):203-207,5.基金项目
国家自然科学基金资助(81271170) （81271170）
