临床与实验病理学杂志2017，Vol.33Issue(2)：125-128,4.DOI:10.13315/j.cnki.cjcep.2017.02.002
胰腺癌中PcG相关蛋白RYBP的表达及临床意义
Expression of PcG related protein RYBP in pancreatic carcinoma and its clinical significance
摘要
Abstract
Purpose To investigate the expression and clinical significance of RINGI and YYI binding protein (RYBP)in pancreatic carcinoma (PC).Methods RYBP expression was detected in 51 cases of PC tissues and paired adjacent nontumor tissues by immunohistochemistry.The correlation between RYBP expression and the survival time of PC patients after surgery was analyzed by Kaplan-Meier method.Results Compared to the expression in adjacent non-tumor tissues,RYBP was significantly lower expressed in PC tissues (P ＜ 0.05).In addition,RYBP expression had a significant correlation with tumor diameter and tumor staging of patients (P ＜ 0.05),but no significant correlation with other characteristics of patients,such as gender,age,smoking,alcohol intake,tumor number,metastasis or CA199 level (P ＞ 0.05).The survival analysis showed that the survival time of PC patients with positive expression of RYBP was significantly longer than patients with negative expression of RYBP (P ＜ 0.05).Conclusion RYBP is significantly lower expressed in PC tissues,which might be involved in the pathogenesis of PC.关键词
胰腺肿瘤/RYBP/细胞凋亡Key words
pancreatic neoplasms/RYBP/cell apoptosis分类
医药卫生引用本文复制引用
罗伟,朱小年,谭盛葵..胰腺癌中PcG相关蛋白RYBP的表达及临床意义[J].临床与实验病理学杂志,2017,33(2):125-128,4.基金项目
国家自然科学基金(81460515) （81460515）
