临床与实验病理学杂志2017，Vol.33Issue(2)：158-161,4.DOI:10.13315/j.cnki.cjcep.2017.02.009
肝细胞癌中Dkk-3与Cyclin D1的表达及临床意义
Expression of Dkk-3 and Cyclin D1 protein in hepatocellular carcinoma and their clinical significance
摘要
Abstract
Purpose To investigate the expression of Dkk3 and Cyclin D1 protein in human hepatocellular carcinoma (HCC) and clinical significance.Methods Immunohistochemistry was used to detect Dkk-3 and Cyclin D1 protein expression level in 80 cases of hepatocellular carcinoma and corresponding para-cancer tissue.Results The expression of Dkk-3 in hepatocellular carcinoma was significantly lower than those in corresponding para-cancer tissue (P ＜ 0.05) and the expression of Cyclin D1 in hepatocellular carcinoma was significantly higher than those in CoTesponding para-cancer tissue (P ＜ 0.05).The up-regulation of Cyclin D1 and the down-regulation of Dkk-3 proteins were correlated with pathologic differentiation degree (P ＜0.05).There was a significant inverse correlation between Dkk3 and Cyclin D1 expression (P =0.044,rs =-0.226).Conclusion The abnormal expression of Dkk-3 and Cyclin D1 gene in human hepatocellular carcinoma suggest that Dkk-3 and Cyclin D1 gene may play an important role in the development and progression of the cancer.The combination deteetion of the two biomarkers may provide valuable data for diagnosis and prognosis estimation of HCC.关键词
肝肿瘤/Dkk-3/Cyclin D1/免疫组织化学Key words
hepatocellular neoplasms/Dkk-3/Cyclin D1/immunohistochemistry分类
医药卫生引用本文复制引用
姚楠,孙景秋,张琼..肝细胞癌中Dkk-3与Cyclin D1的表达及临床意义[J].临床与实验病理学杂志,2017,33(2):158-161,4.基金项目
蚌埠医学院校级课题基金(Byky1316) （Byky1316）
