中南医学科学杂志2017，Vol.45Issue(2)：109-112,144,5.DOI:10.15972/j.cnki.43-1509/r.2017.02.001
PTEN蛋白在胃癌中的表达及临床病理意义
Expression of PTEN in gastric cancer and clinical pathological significance
摘要
Abstract
Objective To investigate the expression of PTEN protein in gastric cancer and clinical pathological significance.Methods Tissue microarray technique and SP Immunohistochemistry method were applied to detect PTEN protein expression in the 140 cases of gastric cancer,the 54 cases of tissue nearby and 64 cases matched non-cancer mucosa and evaluate the influence of abnormal expression of PTEN protein for carcinogenesis and progression of gastric cancer.Results Immunohistochemistry results revealed that the positive rates of PTEN protein expression in matched non-cancer mucosa,tissue nearby and gastric cancer were 83.36％ (19/22),56.25％ (27/48) and 24.44％ (22/90),respectively.The PTEN protein positive expression in gastric cancer were significantly lower than those matched non-cancer mucosa and the tissue nearby (P＜0.05).The positive rates of PTEN expression were 44.83％ (13/29) in well differentiated,26.08％ (6/23) in moderate differentiated,14.58％ (7/48) in poorly differentiated,7.40％ (2/27) in mucinous cancer and 7.69％ (1/13) in signet ring cell cancer,respectively,and the positive expression rates of PTEN between distinct degree of differentiation were significantly different in gastric cancer (P＜0.05).Conclusion The down-regulation of PTEN protein was concerned with carcinogenesis,degree of differentiation,lymphatic metabasis and clinical stage in gastric cancer.关键词
胃癌/PTEN/组织芯片/免疫组织化学Key words
gastric cancer/PTEN/tissue microarray/immunohistochemistry分类
医药卫生引用本文复制引用
罗文,周娟,夏红,苏坚,刘芳,汤欢,苏琦..PTEN蛋白在胃癌中的表达及临床病理意义[J].中南医学科学杂志,2017,45(2):109-112,144,5.基金项目
国家自然科学基金(81102854,81374013). （81102854,81374013）
