中南医学科学杂志2017，Vol.45Issue(2)：140-144,5.DOI:10.15972/j.cnki.43-1509/r.2017.02.008
黄芪甲甙下调CaSR对异丙肾上腺素诱导的缺血缺氧心肌损伤的保护作用
The peotective effect of astragaloside IV mediated calcium sensitivereceptor on ischemia anoxic myocardial induced by isoproterenol
邓纯 1杨云华 2左袁博教 2张雅林 1蒋德林1
作者信息
- 1. 永州市中心医院儿科,湖南 永州 425000
- 2. 南华大学附属第一医院儿科
- 折叠
摘要
Abstract
Objective To explore the protective effects and mechanism of Astragaloside IV mediated calcium sensitive receptor (CaSR) on ischemia anoxic myocardial.Methods 32 SD rats were randomly divided into normal control group,model group (IS0) glucoside,astragaloside IV low dose group (ISO + AST IV 10 mg/kg),astragaloside IV high dose group (ISO + AST IV 20 mg/kg).Observing myocardial tissue pathology change of different groups by HE staining,detecting CK and CK-MB content;detecting CaSR protein expression by Western Blotting method.Results Compared with model group astragaloside IV low dose group and high dose group can reduce the myocardial pathological varying degrees changes,reduce serum CK and CK-MB,lower CaSR protein expression levels (P＜ 0.05).Conclusion Astragaloside IV can protect ischemia anoxic myocardial injury induced by ISO;The mechanism may reduce the CaSR protein expression and effects on myocardial injury.关键词
黄芪甲甙/CaSR/异丙肾上腺素Key words
Astragaloside IV/CaSR/Isoproterenol分类
医药卫生引用本文复制引用
邓纯,杨云华,左袁博教,张雅林,蒋德林..黄芪甲甙下调CaSR对异丙肾上腺素诱导的缺血缺氧心肌损伤的保护作用[J].中南医学科学杂志,2017,45(2):140-144,5.
