中南医学科学杂志2017，Vol.45Issue(2)：145-149,5.DOI:10.15972/j.cnki.43-1509/r.2017.02.009
连续静脉-静脉血液滤过对脓毒症急性肾损伤中性粒细胞明胶酶相关脂质运载蛋白的影响
Impact of continuous venovenous hemofiltration on the plasmalevel of neutrophil gelatinase-associated lipocalin inpatients with septic acute kidney injury
摘要
Abstract
Objective To evaluate whether continuous venovenous hemofiltration (CVVH) affect the plasma level of neutrophil gelatinase-associated lipocalin (pNGAL) in patients with sepsis-acute kidney injury (SAKI).Methods A total of 42 patients with sepsis-induced AKI undergoing CVVH were screened.NGAL was measured in the prefilter and postfilter blood as well as in the ultrafiltrate at the beginning of continuous renal replacement therapy (CRRT) (T0) and 2 h (T2h),4 h (T4h),8 h (T8h),and 12 h (T12h) after the setup of CRRT.The mass conservation principle was used for calculating the mass transfer,plasma clearance,and sieving coefficient.Results The levels of NGAL at the inlet and outlet did not change following the initiation of CVVH (P＞0.05),whereas in the ultrafiltrate,the concentrations decreased significantly (P=0.013).The total mass removal rate,total mass adsorption rate,and plasma clearance remained unchanged over time (P＞0.05),and the sieving coefficient decreased significantly (P=0.007).Conclusions The impact of CVVH on pNGAL in patients with sepsis-induced AKI is limited.Therefore,it does not need to be taken into account when pNGAL is used for evaluating renal progression in patients with septic AKI undergoing CVVH.关键词
急性肾损伤/连续静脉-静脉血液滤过/中性粒细胞明胶酶相关脂质运载蛋白/脓毒症Key words
acute kidney injury/continuous venovenous hemofiltration/neutrophil gelatinase-associated lipocalin/分类
医药卫生引用本文复制引用
戴新贵,郭伟,李琼,邝代斌,黎艳晖,蔡业平..连续静脉-静脉血液滤过对脓毒症急性肾损伤中性粒细胞明胶酶相关脂质运载蛋白的影响[J].中南医学科学杂志,2017,45(2):145-149,5.基金项目
国家自然科学基金(81601708),湘南学院科研课题(2015XB45)资助. （81601708）
