四川中医2017，Vol.35Issue(3)：50-52,3.
青蒿琥酯对大鼠蛛网膜下腔出血后早期脑损伤的保护作用
Protective Effect of Artesunate for Early Brain Injury after Subarachnoid Hemorrhage in Rats
唐荣锐 1颜如冰2
作者信息
- 1. 重庆市璧山区人民医院神经外科,重庆402760
- 2. 第三军医大学重庆市西南医院康复科,重庆400038
- 折叠
摘要
Abstract
Objective:To evaluate the protective effect of artesunate on early brain injury (EBI) after subarachnoid hemorrhage (SAH) in rats.Methods:60 SD rats were randomly divided into controlled group,model group and treatment group and the model rats with SAH were established by intracranial arterial puncture (rats in the controlled group were received with Sham operation).Rats in the controlled group and the model group were given with saline while ones in the treatment group were administrated with artesunate.The neurological scores,brain edema,evans blue dye extravasation and expression level of tight junction proteins (Occludin and ZO-1) were evaluated.Results:Compared with the model group,the treatment of artesunate significantly increased the neurological scores,decreased the brain edema index and permeability of blood-brain barrier (BBB) and attenuated the down-regulation of Occludin and ZO-1 protein.Conclusion:Artesunate can obviously attenuate EBI after SAH in rats,of which mechanism may be associated with down-regulation of Occludin and ZO-1 expression.关键词
青蒿琥酯/蛛网膜下腔出血/早期脑损伤/脑水肿指数/紧密连接蛋白Key words
Artesunate/Subarachnoid hemorrhage/Early brain injury/Brain edema index/Tight junction proteins分类
医药卫生引用本文复制引用
唐荣锐,颜如冰..青蒿琥酯对大鼠蛛网膜下腔出血后早期脑损伤的保护作用[J].四川中医,2017,35(3):50-52,3.
