四川中医2017，Vol.35Issue(3)：60-62,3.
Box-Behnken效应面法优选川贝清咽含片辅料
Excipients Optimization of Chuanbei Qingyan Buccal Tablets with Box-Behnken Response Surface Method
马旻新 1吴诗惠 1韩丽 1朱宁 1杨安东2
作者信息
- 1. 成都中医药大学药学院,中药材标准化教育部重点实验室,四川省中药资源系统研究与开发利用重点实验室——省部共建国家重点实验室培育基地,四川成都611137
- 2. 四川省中医药科学院,四川成都610041
- 折叠
摘要
Abstract
Objective:Optimizing the excipients of Chuanbei Qingyan Buccal Tablets.Methods:With protein powder (soy protein isolated,whey protein =4:1,m/m),menthol,dosage of aspartame as independent variables,lozenges,hardness,disintegration time limit as the dependent variable,the levels of the independent variables of multivariate linear regression and the binomial fitting,the Box-Behnken response surface method optimization fritillary bulb throat lozenges accessories.Results:Selecting the best technological conditions for protein powder (=4:1 soybean separation protein,whey protein,m/m) was 4.36g/16 slices,aspartame is 68.77 mg/16 slices,menthol was 6.82 mg/16 slices.Conclusion:Box-Behnken response surface method is used to clear throat lozenges fritillary bulb accessories optinization is feasible,the mathematical model of the predicted values are in conformity with experimental observations.关键词
川贝清咽含片/Box-Behnken效应面法/制剂辅料Key words
Chuanbei Qingyan Buccal Tablets/The Box-Behnken response surface method/Pharmaceutical adjuncts分类
医药卫生引用本文复制引用
马旻新,吴诗惠,韩丽,朱宁,杨安东..Box-Behnken效应面法优选川贝清咽含片辅料[J].四川中医,2017,35(3):60-62,3.
