山东医药2017，Vol.57Issue(13)：5-8,4.DOI:10.3969/j.issn.1002-266X.2017.13.002
胃癌组织中IL-33的表达变化及意义
Expression of IL-33 in gastric carcinoma and its significance
摘要
Abstract
To investigate the expression of IL-33 in gastric carcinoma tissues and its significance.Methods Cancer tissues and adjacent tissues of 98 patients with gastric cancer were selected, among whom, there were 16 cases with early gastric cancer, 82 cases with advanced gastric cancer, 76 cases with lymph node metastasis and 22 cases without lymph node metastasis.Meanwhile, we selected 36 cases of normal gastric tissues from healthy people as the control group.Immunohistochemical S-P method and real-time PCR were applied to detect the expression of IL-33 and its mRNA in gastric carcinoma tissues as well as in normal gastric tissues.We analyzed the relationship between the expression of IL-33 and clinicopathological features of gastric carcinoma tissues.Survival curves between IL-33 expression positive and negative patients were made using the Kaplan Meier method, and the median survival time was compared.Results The positive rate of IL-33 expression in gastric cancer tissues was higher than that in normal gastric tissues (P<0.05).No significant difference was found in the positive rate of IL-33 expression between in early gastric cancer and lymph node metastasis-negative gastric cancer tissues and in the normal gastric tissues (all P>0.05), while significant difference was found between in advanced gastric cancer and lymph node metastasis-positive gastric cancer tissues and in the normal gastric tissues (all P<0.05).The relative expression of IL-33 mRNA in gastric cancer tissues was higher than that in the normal gastric tissues (P<0.05).After the comparison of those between gastric cancer tissues with and without lymph node metastasis, significant difference was found (P<0.05).The expression of IL-33 was not related with gender, age, tumor growth and tumor size (all P>0.05), but it was correlated with tumor differentiation, tissue infiltration, lymph node metastasis, distant metastasis and clinical stage (all P<0.05).The median survival time was 30.6 months in IL-33 negative patients and 22.7 months in patients with positive IL-33 expression, P=0.001.Conclusion The increment on the level of IL-33 in gastric cancer tissues indicates that IL-33 may be involved in the occurrence and development of gastric cancer and predict poor prognosis.关键词
胃肿瘤/白细胞介素33/淋巴结转移/预后Key words
stomach neoplasms/interleukin-33/lymph node metastasis/prognosis分类
医药卫生引用本文复制引用
夏兵祥,李凡,王轩,袁振华,郑苏文,张业伟..胃癌组织中IL-33的表达变化及意义[J].山东医药,2017,57(13):5-8,4.基金项目
国家自然科学基金面上项目(61371066) （61371066）
江苏省医学重点人才资助项目(RC2011090) （RC2011090）
江苏省重点研发计划(社会发展)(BE2015720) （社会发展）
江苏省六大高峰人才项目(WSW-041). （WSW-041）
