山东医药2017，Vol.57Issue(13)：13-16,4.DOI:10.3969/j.issn.1002-266X.2017.13.004
上皮性卵巢癌组织中FOXC1的表达变化及意义
Expression changes and significance of FOXC1 in human epithelial ovarian cancer
摘要
Abstract
To investigate the expression changes and significance of fork box protein C1 (FOXC1) in human epithelial ovarian cancer (EOC).Methods The expression of FOXC1, E-cadherin and Vimentin in 30 cases of benign EOC tissues, 30 cases of borderline ECO tissues and 70 cases of ECO tissues was detected by immunohistochemical SP staining.The ovarian cancer patients were followed up for 3 years, and the 3-year cumulative survival rate was compared between ovarian cancer patients with positive and negative FOXC1, E-cadherin and Vimentin.Results ①The positive expression rates of FOXC1 and E-cadherin in the borderline ECO tissues were decreased, and the positive expression rate of Vimentin was increased as compared with those of the benigh ECO tissues (P<0.05).② The positive expression rate of E-cadherin was 28.6% (20/70), the positive expression rate of Vimentin was 15.7% (11/70) in ovarian cancer tissues with positive expression of FOXC1, the expression of FOXC1 was positively correlated with the expression of E-cadherin (r=0.446, P=0.000), and was correlated with Vimentin expression (r=-0.295, P=0.014).③ The expression of FOXC1 protein in EOC tissues was negatively correlated with lymph node metastasis, dualistic type and grading, and the protein expression of E-cadherin and Vimentin was correlated with lymph node metastasis, clinical classification, dualistic type and grading (all P<0.05).④The 3-year cumulative survival rates of EOC patients with positive expression of FOXC1 and E-cadherin was 82.1% and 80.6%, respectively, which were higher than those in patients with negative expression of FOXC1 and E-cadherin (69.0% and 69.2%).The 3-year cumulative survival rates of EOC patients with positive expression of Vimentin was 70%, which was significantly lower than that in patients with negative Vimentin (80%) (all P<0.05).Conclusions The expression of FOXC1 is decreased in ovarian cancer tissues, and the loss expression of FOXC1 may be a role in the process of EMT.Meanwhile,FOXC1 expression may be involved in the occurrence and development of ovarian cancer and can be used as an indicator to evaluate prognosis.关键词
上皮性卵巢癌/叉头框蛋白C1/上皮间质转化/上皮性黏钙蛋白/波形蛋白Key words
epithelial ovarian carcinoma/fork box protein C1/epithelial-mesenchymal transition/E-cadherin/Vimentin分类
医药卫生引用本文复制引用
黄玲,任琛琛,杨立,白杨,薛景戈,刘灵,李倩..上皮性卵巢癌组织中FOXC1的表达变化及意义[J].山东医药,2017,57(13):13-16,4.基金项目
河南省科技厅科技攻关项目(162102310131) （162102310131）
河南省科技厅科技攻关项目(142300410205). （142300410205）
