兽类学报2016，Vol.36Issue(2)：184-199,16.DOI:10.16829/j.slxb.201602007
雌激素受体α和β免疫反应在雄性和雌性棕色田鼠脑区分布的比较
Sex differences in the distributions of estrogen receptor alpha and beta immunoreactivity in the forebrains of male and female mandarin voles
摘要
Abstract
Differences in the social behavior of monogamous and polygamous rodents may be related to estrogen receptor subtypes (ERs).The distribution of estrogen receptor α (ERαt) and β (ERβ) immunoreactivity in polygamous rats and mice and ERα immunoreactivity in the central nervous system of monogamous male prairie voles have been reported,but no data on the ERβ distribution in monogamous voles is available.In the present study,the number of ERα and ERβ immunoreactive (IR) cells in the forebrain of male and female mandarin voles (Microtus mandarinus) were compared using immunocytochemistry.We found that ERo-IR and ERβ-IR cells were mainly found in nuclei in mandarin voles.ERα-IR and ERβ-IR cells were widely distributed throughout the forebrain and expression overlaps in many forebrain areas.However,the number of cells and degree of receptor expression per cell were different for each ER subtype.In the medial preoptic nucleus (MPN),bed nucleus of the stria terminalis (BNST) and medial amygdaloid nucleus (MeA) females had a higher ERα density than did males.The opposite pattern was found in the MPN and BNST where males had a higher ERβ density than did females.These results provide an important neuroanatomical basis for enhancing our understanding of how estrogens work through ERα and ERβ to regulate important processes including social behavior.关键词
雌激素受体α/雌激素受体β/前脑/单配制田鼠/棕色田鼠Key words
Bed nucleus of the stria terminalis (BNST)/Estrogen receptor α (ERα)/Estrogen receptor β (ERβ)/Mandarin vole/Medial preoptic nucleus (MPN)分类
生物科学引用本文复制引用
何凤琴,张巨武,方刚,刘凌,王波,郭春林..雌激素受体α和β免疫反应在雄性和雌性棕色田鼠脑区分布的比较[J].兽类学报,2016,36(2):184-199,16.基金项目
National Natural Science Foundation of China (61173113) （61173113）
Science and Technology Research and Development Foundation of Shaanxi (2015JM3116) （2015JM3116）
Science and Technology Program of Xi'an (CXY1443WL09) （CXY1443WL09）
