水生生物学报2017，Vol.41Issue(3)：491-496,6.DOI:10.7541/2017.63
饲料脂肪水平对大菱鲆幼鱼TOR信号通路的影响
EFFECTS OF DIETARY LIPID LEVELS ON TOR PATHWAY IN JUVENILE TURBOT (SCOPHTHALMUS MAXIMUS L.)
摘要
Abstract
This study investigated the effects of dietary lipid levels on the TOR pathway in juvenile turbot using diets containing graded levels of lipid 11.69% (L11.69) and 16.58% (L16.58) (dry weight) to feed triple groups of juvenile turbot (8.6±0.01 g) for a 97d trial. The lipids level in diet did not impact survival rate and SGR. Compared those in L11.69 group, L16.58 group increased the gene expression of TOR, 4EBP1 but decreased 4EBP2 in liver, and it in-creased the phosphorylation of pAKT-S473, pAKT-T308, pmTOR-S2448, and p4EBP1-T37/46. In the muscle, L16.58 group had decreased TOR and 4EBP1 associated with pAKT-S473, pmTOR-S2448 and p4EBP1-T37/46 compared with those in L11.69 group. In conclusion, L16.58 diet can activate TOR pathway in liver while partially suppress TOR pathway in muscle of junvenile turbot compare with L11.69 diet.关键词
大菱鲆/脂肪水平/基因表达/磷酸化/TOR信号通路Key words
Turbot/Dietary lipid level/Gene expression/Phosphorylation/TOR pathway分类
农业科技引用本文复制引用
唐卓懿,崔坤,陈强,谭朋,廖凯,麦康森,艾庆辉..饲料脂肪水平对大菱鲆幼鱼TOR信号通路的影响[J].水生生物学报,2017,41(3):491-496,6.基金项目
国家重点基础研究发展计划(973计划)养殖鱼类蛋白质高效利用的调节机制(2014CB138600)资助 Supported by Mechanisms of Protein Efficient Utilization in Farmed Fish, National Program on Key Basic Research Projects (973 Program) (2014CB138602) （973计划）
