现代检验医学杂志2017，Vol.32Issue(2)：117-118,122,3.DOI:10.3969/j.issn.1671-7414.2017.02.032
脂蛋白相关磷脂酶A2在颈动脉斑块性脑梗死中的临床意义
Clinical Study of LP-PLA2 in Carotid Plaques Cerebral Infarction Patients
文关良 1剌梅1
作者信息
- 1. 乾县中医医院检验科,陕西乾县713300
- 折叠
摘要
Abstract
Objective To study the relationship between the lipoprotein associated phospholipase A2 (LP-PLA2) with the carotid plaques cerebral infarction,and study the predictive value of LP-PLA2 in carotid artery plaque stability.Methods According to the results of color doppler ultrasound examination of carotid artery,169 patients with cerebral infarction were random divided into cerebral infarction with carotid plaques group (101 patients) and cerebral infarction without carotid plaques group(68 patients) groups.According to the nature of plaque stability of carotid plaques.101 cases of cerebral infarction with carotid plaques group was divided into plaques group 30 cases and 71 cases of unstable plaque group.Set healthy control groups at the same time.Then detected level of LP-PLA2 for each patient by the method of double antibody sandwich enzyme-linked immunosorbent (ELISA).To evaluate the predictive value of LP-PLA2 in carotid artery plaque stability by mapping the receiver-operating characteristic (ROC) curve.Results The level of LP-PLA2 (212.90± 117.69 ng/ml) in carotid plaques group were significantly higher than those without plaque group (127.70 ± 57.96 ng/ml,t=3.016,P ＜0.01).It was not show significantly difference between no plaque group and healthy control group (108.34 ± 42.58 ng/ml,t=0.779,P＞0.05).But it showed significantly different between the unstable plaque group (236.24 ± 128.33 ng/ml)and stability plaques group (157.65±59.27 ng/ml,t=3.442,P＜0.01).Conclusion The LP-PLA2 of plasma could be involved in the development of atherosclerosis plaques.The LP-PLA2 can certain correlation with cerebral infarction of carotid plaques,can well evaluate the stability of carotid plaques.关键词
颈动脉斑块/脑梗死/脂蛋白相关磷脂酶A2/斑块稳定性Key words
carotid plaques/cerebral infarction/LP-PLA2/plaque stability分类
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文关良,剌梅..脂蛋白相关磷脂酶A2在颈动脉斑块性脑梗死中的临床意义[J].现代检验医学杂志,2017,32(2):117-118,122,3.
