实用医学杂志2017，Vol.33Issue(3)：346-349,4.DOI:10.3969/j.issn.1006-5725.2017.03.004
FCER2基因rs28364072位点多态性与哮喘的相关性
Correlation between FCER2 gene rs28364072 polymorphism and asthma
摘要
Abstract
Objective To determine whether rs28364072 polymorphism in the low-affinity IgE receptor (FCER2)is associated with asthma risk in Chinese Han nationality asthmatics.Methods 120 cases of asthmatics and 116 healthy control subjects were enrolled in this study.DNA was purified from peripheral blood,and genotyping of rs28364072 SNP was performed by PCR and Sanger sequencing.The clinical indexes were compared between asthmatic subjects.Results A significant difference was found in the distributions of the genotyges (TT,TC,CC)and allele frequency among populations in north Indian,Saudi Arabian,Romas and Chinese Han nationality.A significant difference was also found in the distributions of the genotyges (TT,TC,CC) between asthmatic subjects and controls.Significant difference was observed in the allele (T/C) frequency between asthmatic subjects and healthy controls.The presence of C allele of GLCCI1 gene was found to be a greater risk factor in asthmaticsubjects compared with the healthy controls.The odds ratio (OR) of CC and CC+TC were 2.73 (1.19 ～ 6.23),2.05 (1.21 ～ 3.48),respectively.There was significant difference in the ACT score,EOS％ between CC and TT genotyge.Conclusion The minor alleles "C" of rs28364072 SNP was significantly associated with the increase of asthma risk in asthma patients of of Han Nationality of Chinese.关键词
哮喘/FCER2基因/基因多态性Key words
Asthma/FCER2 gene/SNP引用本文复制引用
邱玉明,李剑雄,肖少娴..FCER2基因rs28364072位点多态性与哮喘的相关性[J].实用医学杂志,2017,33(3):346-349,4.基金项目
2016年深圳市宝安区科技局课题(编号:2016CX184) （编号:2016CX184）
