实用医学杂志2017，Vol.33Issue(3)：402-404,3.DOI:10.3969/j.issn.1006-5725.2017.03.018
血液净化治疗利尿剂抵抗肾病综合征水肿患者的疗效
Efficacy of blood purification therapy on diuretic resistance in patients withnephrotic edema
摘要
Abstract
Objective To investigate the efficacy and safety of blood purification therapy in the treatment of diuretic resistance in patients with nephrotic edema.Methods 40 cases of primary nephrotic syndrome with diuretic resistance in our hospital were randomly divided into hemodialysis (HD) group and continuous blood purification (CVVH) group and each group were 20 cases.All the patients were given basic treatment (lipid modulation,anticoagulation and glucocorticoid) and the observation time was 4 weeks.The changes of biochemical indexes (24 h urine protein,plasma albumin,serum urea nitrogen and serum creatinine) were observed before and after treatment in two groups.In addition,the complications of four groups were recorded.Results After blood purification treatment,urinary volume of two groups were significantly increased,the quantity of 24 h urinary protein and serum albumin were significantly improved,levels of serum urea nitrogen and serum creatinine were significantly decreased.The differences were statistically significant (P ＜ 0.05 or P ＜ 0.01).Compared with HD group,the urine volume increased more obviously in CVYH group after 2 weeks' treatment (P ＜ 0.05).The same time,24 h urinary protein was reduced and plasma albumin was improved more significantly (P ＜ 0.05),levcls of serum urea nitrogen and serum creatinine were not differ between the two groups (P ＞ 0.05).There was no difference in urine volume and renal function between the two groups (P ＞ 0.05) after 4 weeks' treatment.24 h urinary protein was significantly decreased and serum albumin was significantly higher than HD group (P ＜ 0.05).There were no serious complications in the two groups.Conclusion Blood purification in the treatment of diuretic resistance in patients with nephrotic edema is safe and effective.Continuous blood purification treatment can effectively alleviate nephrotic edema with diuretic resistance,promote the recovcry of renal function and improve the prognosis of kidney disease.关键词
肾病综合征/利尿剂抵抗/水肿/血液净化Key words
Nephrotic syndrome/Diuretic resistance/Edema/Blood purification引用本文复制引用
吴泽成,汤跃武,李良志,史继红,何先红,刘雷..血液净化治疗利尿剂抵抗肾病综合征水肿患者的疗效[J].实用医学杂志,2017,33(3):402-404,3.基金项目
重庆市万州区科学技术委员会科技计划项目(编号:201503005) （编号:201503005）
