实用医学杂志2017，Vol.33Issue(4)：554-557,4.DOI:10.3969/j.issn.1006-5725.2017.04.014
床边快速检测NGAL对急诊冠脉介入后造影剂所致急性肾损伤预测的多中心研究
Multicenter clinical study of the predictive value of neutrophil gelatinase-associated lipocalin for contrast-induced acute kidney injury after emergency percutaneous coronary intervention in patients with relative normal renal function
摘要
Abstract
Objective To explore the predictive value of neutrophil gelatinase associated lipocalin (NGAL) for contrast-induced acute kidney injury (CI-AKI) after emergency percutaneous coronary interventions (PCI) in patients with relative normal renal function.Methods A total of 73 patients with relative normal renal function undergoing PCI were enrolled in this prospective multicenter clinical study.Serum NGAL was measured by point-of-care test.Receiver operating characteristic (ROC) curve was used to analyze the diagnostic value of NGAL for CI-AKI.Results CI-AKI occurred in 5 patients (6.85％).The concentration of NGAL was higher in the CI-AKI group than in the non-CI-AKI group.ROC curve indicated that the area under the receiver operating characteristic was 0.755,0.761 and 0.809,respectively.Conclusions Serum NGAL at baseline,4 h and 8 h after procedure are served as a good biomarker for early diagnosis of CI-AKI after PCI.Therefore,NGAL might become an early and quick marker for CI-AKI in the future.关键词
中性粒细胞明胶酶载脂蛋白/急性心肌梗死/经皮冠状动脉/造影剂肾病Key words
Neutrophil gelatinase associated lipocalin/Acute myocardial infarction/Percutaneous coronary intervention/Contrast-induced acute kidney injury引用本文复制引用
王坤,谭宁,刘勇,陈纪言,谢年谨,余丹青,薛凌,叶健烽,梁岩..床边快速检测NGAL对急诊冠脉介入后造影剂所致急性肾损伤预测的多中心研究[J].实用医学杂志,2017,33(4):554-557,4.基金项目
2012年中国医师协会阳光心血管研究基金项目(编号:SCRFCMDA201216) （编号:SCRFCMDA201216）
2014年广东省科技厅公益研究与能力建立项目(编号:2014A020212635) （编号:2014A020212635）
