实用医学杂志2017，Vol.33Issue(5)：731-735,5.DOI:10.3969/j.issn.1006⁃5725.2017.05.015
血清维生素D水平及添加治疗对多发性硬化患者预后的影响
Levels of vitamin D and the effect of added treatment on Multiple Sclerosis
摘要
Abstract
Objective To evaluate the serum 25?hydroxy vitamin D3 level in patients with multiple sclerosis(MS)and normal healthy population,as well as the correlation between addition of oral 1,25?hydroxy vitamin D3 and the prevention of MS relapse and progression. Methods There were 60 cases in the relapsing?remitting MS(RRMS)group and 68 cases in the healthy group,respectively;and the differences in the sex,age, serum 25?hydroxy vitamin D3 level of the two groups were counted and evaluated. In addition ,the 60 cases of patients were divided randomly into the hormone therapy group and the addition treatment group ,with 30 cases in each group;the addition treatment group was added oral calcitriol soft capsules on the basis of the hormone therapy group;EDSS score evaluation was conducted on the two groups 6,12 and 24 months after treatment,the relapse frequency was counted after 24 months,and the relapse interval was calculated. Results The serum 25?hydroxy vitamin D3 levels in the patient group and the healthy group were(18.75 ± 8.35)nmol/L and(23.28 ± 9.31)nmol/L, respectively. There were statistically significant differences in the relapse frequency (P < 0.01),the relapse interval(P < 0.05),and EDSS score(after 24 months)(P < 0.05)between the hormone therapy group and the addition treatment group after treatment;while the differences in the EDSS score (after 6 months)(P = 0.457) and the EDSS score(after 12 months)(P = 0.118)between the two groups showed no statistically significance. Conclusion The serum 25?hydroxy vitamin D3 level in MS patients was markedly lower than that in normal healthy population. Addition of 1,25?hydroxy vitamin D3 contributes to preventing the relapse rate of MS and extending the relapse interval;in addition,maintaining long?term of oral 1,25?hydroxy vitamin D3 facilitates to delaying the progression of disabled disease.关键词
血清维生素D水平/1,25⁃羟维生素D3/25⁃羟维生素D3/多发性硬化/扩展残疾状态量表Key words
Serum vitamin D level/1/25⁃hydroxy vitamin D3/25⁃hydroxy vitamin D3/Multiple sclerosis/Expanded Disability Status Scale引用本文复制引用
罗高权,刘玲,李鸥,项薇,武肖娜,黎春镛..血清维生素D水平及添加治疗对多发性硬化患者预后的影响[J].实用医学杂志,2017,33(5):731-735,5.基金项目
广东省医学科学技术研究基金(编号:A2014487) （编号:A2014487）
