实用医学杂志2017，Vol.33Issue(6)：901-904,4.DOI:10.3969/j.issn.1006-5725.2017.06.014
RET基因在宫颈鳞癌中的表达及与预后的关系
Expression of RET gene in cervical squamous cell carcinoma
摘要
Abstract
Objective To explore the expression of RET in cervical squamous carcinoma tissues and evaluate its relationship with cervical squamous carcinoma clinical pathological indexes and its prognostic value. Methods The expression and distribution of RET in normal cervical tissues ,CINⅠ,CINⅡ& CINⅢ and cervical squamous carcinomas tissues were detected by immunohistochemistry in wax blocks. Clinical data and follow-up data are integrated to analyze its relationship with clinical pathological factors and prognosis value. Results The positive rate of RET protein in cervical squamous carcinomas tissues is higher than in other tissues.The positive rate was related to FIGO stage and lymph node metastasis(P<0.05),and not related with the age of patients or the degree of tumor differentiation(P>0.05). The result of survival analysis with Kaplan-Meier method showed poorer disease-free survival time in the patients with high expression of RET (P < 0.05). Prognostic analysis of patients with cervical cancer through COX proportional hazard regression model suggested that RET expression was an independent prognostic factor. Conclusions RET has been involved in the progression ,FIGO stage and metastasis of cervical squamous cell carcinomas.关键词
子宫颈鳞状细胞癌/转染期间重排基因RET/生存分析/预后Key words
Cervical squamous cell carcinoma/RET/Survival analysis/Prognosis引用本文复制引用
李华英,邓建超,黄守国..RET基因在宫颈鳞癌中的表达及与预后的关系[J].实用医学杂志,2017,33(6):901-904,4.基金项目
海南省自然科学基金资助项目(编号:20158288) （编号:20158288）
