实用医学杂志2017，Vol.33Issue(6)：979-982,4.DOI:10.3969/j.issn.1006-5725.2017.06.035
阿托西班对反复着床失败后冻融周期囊胚移植妊娠结局的影响
Influence of atoxiban on pregnancy outcome in patients with repeated implantion failure in Blastcyst Thawed Embryo Transfer
刘杰 1郑洁 1雷亚兰 1文晓凤 1夏敏 1孙虹1
作者信息
- 1. 430070 湖北省武汉市,湖北省妇幼保健院生殖医学中心
- 折叠
摘要
Abstract
Objective To investigate the influence of atosiban on the pregnancy outcome in patients with repeated implantation failure(RIF)in blastcyst thawed embryo transfer(bTET) Methods From January 2014 to December 2015,a total of 262 RIF patients undergoing bTET were retrospectively studied. They were divided into study group with a single bolus dose (6.75 mg/0.9 mL,iv) of atosiban before bTET (n = 94),and control groupwithout atosiban(n = 168). Results The clinical pregnancy rate(57.41%),implantation rate(38.41%) and living-birth rate(46.81%) of study group were significantly higher than those of control group (41.12%, 28.32% and 33.93% respectively;P < 0.05). Although the abortion rate of study group was higher than that of control group(14.82% vs 13.04%),both the ectopic pregnancy rate(3.70%) and the multiple pregnancy rate (16.67%) were lower than those of control group(5.79% and 17.39%),and there was no statistical difference (P > 0.05). Conclusion Atosiban treatment before embryo transfer may improve pregnancy outcomes of RIF patients in bTET.关键词
阿托西班/反复种植失败/冻融胚胎移植/临床妊娠率Key words
Atosiban/Repeated implantation failure/Thawed embryo transfer/Clinical pregnancy rate引用本文复制引用
刘杰,郑洁,雷亚兰,文晓凤,夏敏,孙虹..阿托西班对反复着床失败后冻融周期囊胚移植妊娠结局的影响[J].实用医学杂志,2017,33(6):979-982,4.
