现代妇产科进展2017，Vol.26Issue(4)：241-245,5.DOI:10.13283/j.cnki.xdfckjz.2017.04.001
子宫内膜癌中错配修复(MMR)蛋白表达缺失筛查Lynch综合征及其临床病理特点
The MMR(Mismatch repair) protein deficiency in endometrial carcinoma:the significance in the detection of Lynch syndrome and the correlation with clinical and pathological characteristics
曾桢 1董颖 2张岩1
作者信息
- 1. 北京大学第一医院 妇产科 北京 100034
- 2. 北京大学第一医院 病理科 北京 100034
- 折叠
摘要
Abstract
Objective:To analyze the significance of mismatch repair(MMR) protein deficiency in the detection of Lynch syndrome,and the correlation with clinical and pathological characteristics.Methods:313 endometrial carcinoma patients treated in Peking University First Hospital between Dec.2011 and July.2015 were reviewed.The expression of MMR protein (MLH1/MSH2/MSH6/PMS2) was assessed by immunohistochemistry (IHC).Results:Lynch syndrome was diagnosed in 22 patients (7.0%) according to the clinical criteria,meanwhile loss of MMR expression was found in 49 patients (15.7%).Patients with possible diagnosis of Lynch syndrome tended to have higher possibility of MMR protein deficiency (P=0.011);in which MSH6 protein deficiency(P=0.004) did the main contribution.The deficiency of MSH2 and MSH6 were associated with less proportion of hypertension (P=0.002,P=0.045),higher possibility of lymph node metastasis (P=0.025,P=0.020) and poor tumor differentiation (P=0.030,P=0.010),besides the deficiency of MSH6 was correlated with younger age (P=0.021).Conclusion:The deficiency of MMR detected by IHC was more prevalent in possible Lynch syndrome patients,which could possible help detecting Lynch syndrome.The MMR protein deficiency was correlated with younger age,lymph node metastasis and poor tumor differentiation.关键词
子宫内膜癌/错配修复(MMR)/Lynch综合征Key words
Endometrial carcinoma/Mismatch repair (MMR)/Lynch syndrome分类
医药卫生引用本文复制引用
曾桢,董颖,张岩..子宫内膜癌中错配修复(MMR)蛋白表达缺失筛查Lynch综合征及其临床病理特点[J].现代妇产科进展,2017,26(4):241-245,5.
