现代妇产科进展2017，Vol.26Issue(4)：276-279,4.DOI:10.13283/j.cnki.xdfckjz.2017.04.010
硫氢化钠通过PI3K/AKT信号通路促进子宫内膜基质细胞增殖
Hydrogen sulfide stimulate the proliferation of endometrial stromal cells by activation of PI3K/AKT signaling pathway
摘要
Abstract
Objective:To explore the effect of hydrogen sulfide upon the proliferation of endometrial stromal cells.Methods:Immunohistochemical characteriaztion of Hydrogen sulfide synthase,Cystathionine-β-synthase (CBS) and Cystathionine-gamma-lyase (CSE) in endometriosis (EMS) lesions and normal endometrium.Normal human endometrial stromal cell line (ESCL) was recruited for proliferation assay with sodium hydrosulfide and PI3K/AKT pathway specific inhibitor LY294002 treatment.Results:The expressions of CBS and CSE in ectopic endometrium were higher than those in normal endometrium,when compared to the expression of CBS and CSE in endometrial stromal cell,glandular epithelial cells was lower.Hydrogen sulfide could increase the proliferation of ESCL and could be partially abolished by LY294002(P<0.01).Conclusion:Hydrogen sulfide could stimulate endometrial stromal cell proliferation in vitro at least partially via PI3K/Akt signaling pathway,which might contribute to the pathogenesis of endometriosis.关键词
硫化氢/硫氢化钠/子宫内膜间质细胞/子宫内膜异位症/PI3K/AKT/增殖Key words
H2S/NaHS/Endometrial stromal cells/Endometriosis/PI3K/AKT/Proliferation分类
医药卫生引用本文复制引用
曹艳玲,雷莎婷,赵栋,李明清,孙静..硫氢化钠通过PI3K/AKT信号通路促进子宫内膜基质细胞增殖[J].现代妇产科进展,2017,26(4):276-279,4.基金项目
国家自然科学基金面上项目(No:81471436) （No:81471436）
