右江医学2017，Vol.45Issue(2)：146-149,4.DOI:10.3969/j.issn.1003-1383.2017.02.005
缺血性股骨头坏死患者血清骨形态形成拮抗蛋白1的水平及其临床意义
Expression level and clinical significance of serum GREM1 in patients with ischemic necrosis of femoral head
摘要
Abstract
Objective To detect the expression level of serum GREM1 in patients with ischemic necrosis of femoral head (INFH),so as to explore its clinical significance.Methods 58 cases of INFH admitted to hospital from April,2016 to October,2016 were selected as observation group,and 76 healthy subjects who underwent physical examination in physical examination center in the same period were chosen as control group.And then,the serum levels of GREM1 of the two groups were measured by enzyme linked immunosorbent assay(ELISA),and C reactive protein(CRP) was detected by routine method.In addition,difference of the expressions of GREM1 and CRP levels between the two groups was compared,and the linear correlation between them in the observation group was analyzed.Results The levels of GREM1 and CRP in the observation group improved more significantly than those of the control group(P<0.01).In the observation group,the level of serum GREM1 in patients with stage Ficat Ⅲ/Ⅳ was higher than that in patients with stage Ficat Ⅰ/Ⅱ(P<0.001).Pearson linear correlation analysis showed that there was no significant correlation between serum GREM1 level and CRP level in the observation group(r=-0.118,P>0.05).Conclusion The level of serum GREM1 in patients with INFH increases,which suggests that it may involve in the occurrence and development of INFH.关键词
股骨头坏死/骨形态形成拮抗蛋白1/C-反应蛋白Key words
INFH/GREM1/CRP分类
医药卫生引用本文复制引用
廖林波,梁俊卿,农峰,吴昭元,唐毓金,谢克恭,卢贤哲,蓝常贡..缺血性股骨头坏死患者血清骨形态形成拮抗蛋白1的水平及其临床意义[J].右江医学,2017,45(2):146-149,4.基金项目
广西科技攻关项目(桂科攻0898006) （桂科攻0898006）
