眼科新进展2017，Vol.37Issue(4)：335-337,3.DOI:10.13389/j.cnki.rao.2017.0084
玻璃体内注射雷珠单抗治疗重度非增生型糖尿病视网膜病变伴黄斑水肿后患者脉络膜厚度的变化
Changes of choroidal thickness after ranibizumab treatment for non-proliferative diabetic retinopathy with macular edema
摘要
Abstract
Objective To observe the changes of choroidal thickness after ranibizumab treatment for non-proliferative diabetic retinopathy (NPDR) with macular edema,and determine the association between choroidal thickness and visual acuity.Methods Twenty-three eyes from 23 patients diagnosed with NPDR and diabetic macuiar edema were treated with 3 monthly intravitreal injections of ranibizumab.The subfoveal choroidal thickness and central macular thickness were measured,and the best corrected visual acuity was recorded.Changes of subfoveal choroidal thickness,correlation between subfoveal choroidal thickness and best corrected visual acuity were assessed at 3 months follow-up.Results After 3 monthly anti-VEGF treatments,subfoveal choroidal thickness and central macular thickness decreased significantly,there was no statistical difference at 1 month and 2 months compared with pre-treatment (all P ＞ 0.05),but there was statistical differences at 3 months compared with pre-treatment (P =0.04,0.01).In the treatment,the best corrected visual acuity increased gradually,there was no statistical difference at 1 month and 2 months compared with pre-treatment (all P ＞ 0.05),but there was statistical differences at 3 months compared with pre-treatment (P =0.04).Before the treatment,the subfoveal choroidal thickness was positive correlated with macuiar retinal thickness (R2 =0.94,P =0.00);And the best corrected visual acuity before treatment and 3 months after treatment had a positive correlation (R2 =0.93,P =0.00;R2 =0.82,P =0.00).There was a positive correlation between central macular thickness and best corrected visual acuity at 3 months after treatment (R2 =0.83,P =0.00).There was a positive correlation in the best corrected visual acuity between before treatment and 3 months after treatment (R2 =0.84,P =0.00).Conclusion The subfoveal choroidal thickness is a clinical index to evaluate the efficacy of anti-VEGF in the treatment of diabetic macuiar edema.Baseline subfoveal choroidal thickness can be considered as one of the indicators of clinical efficacy in the short term.关键词
非增生型糖尿病视网膜病变/黄斑水肿/脉络膜厚度Key words
non-proliferative diabetic retinopathy/macular edema/choroidal thickness分类
医药卫生引用本文复制引用
冯超,徐冲,阎静,吴建华..玻璃体内注射雷珠单抗治疗重度非增生型糖尿病视网膜病变伴黄斑水肿后患者脉络膜厚度的变化[J].眼科新进展,2017,37(4):335-337,3.基金项目
湖北省卫生计生科研基金资助项目(编号:WJ2015MB258) （编号:WJ2015MB258）
爱尔眼科医院集团科研基金项目(编号:AF141D04)Hubei Province Health and Family Planning Scientific Research Project (No:WJ2015MB258) （编号:AF141D04）
Science Research Foundation of Aier Eye Hospital Group (No:AF141D04) （No:AF141D04）
