眼科新进展2017，Vol.37Issue(4)：344-347,4.DOI:10.13389/j.cnki.rao.2017.0087
干眼患者泪膜脂质层厚度检测及其与眼表体征的相关性分析
Measurement of tear film lipid layer thickness in dry eye patients and its relationship with ocular surface signs
摘要
Abstract
Objective To measure the tear film lipid layer thickness (LLT) in dry eye patients and investigate the correlations of LLT with ocular surface signs.Methods One hundred and thirty dry eye patients (130 eyes),including 64 meibomian gland dysfunction (MGD) patients and 66 non-MGD patients,were included in this study.LLT,break-up time (BUT),fluorescein staining (FL),Marx's line (ML) score and Schirmer I test were performed and examined.The distribution of LLT in different age groups and the correlations between LLT and other examinations were analyzed.Results There was significant difference in LLT among different age groups (P =0.007),while LLT was not significantly different between male and female in each age group (P ＞ 0.05).LLT was positively correlated with age (r =0.334,P ＜ 0.001) and was not correlated with sex (r =0.107,P =0.226).LLT was positively correlated with upper eyelid ML score (r =0.295,P =0.001) and lower eyelid ML score (r =0.233,P =0.008).There was no significant correlation of LLT with BUT,FL or Schirmer Ⅰ test (all P ＞0.05).In the MGD group,there were positive correlations of LLT with upper eyelid ML score and lower eyelid ML score (all r =0.306,P =0.014),and no correlation of LLT with other examinations (all P ＞ 0.05).In the non-MGD group,there was no correlation of LLT with other examinations (all P ＞ 0.05).In a multivariate linear regression analysis,age and upper eyelid ML score were significantly related to LLT (β =0.254,P =0.005 for age and β =0.207,P =0.022 for upper eyelid ML score) in all dry eye patients.Age was the only factor related to LLT (β =0.382,P =0.002) in the MGD group.Upper eyelid ML score and lower eyelid ML score were higher in the MGD group than the non-MGD subgroup (all P ＜ 0.001).Conclusion LLT is positively correlated with age and ML score in dry eye patients.The measurement of tear film LLT,as an auxiliary examination in the diagnosis of dry eye disease,should be analyzed with the influential factors including age.关键词
泪膜脂质层/干眼/睑板腺功能障碍/眼表体征/年龄Key words
tear film lipid layer/dry eye/meibomian gland dysfunction/ocular surface signs/age分类
医药卫生引用本文复制引用
李妍,桑璇,王晓然,杨柳,贺雄军,王智崇,陆晓和..干眼患者泪膜脂质层厚度检测及其与眼表体征的相关性分析[J].眼科新进展,2017,37(4):344-347,4.基金项目
广东省前沿与关键技术创新专项资金(省重大科技专项)(编号:2015B020227001) （省重大科技专项）
广州市科技计划科学研究专项(重点项目)(编号:15020083) （重点项目）
眼科学国家重点实验室专项经费(编号:2012PI05) （编号:2012PI05）
中山大学中山眼科中心“五个五培育项目” Guangdong Frontier And Key Technology Innovation Special Funds (Major Science and Technology) (No:2015B020227001) （Major Science and Technology）
Scientific Research Project of Guangzhou Science and Technology Program (Key Project) (No:15020083) （Key Project）
Special Funds of the State Key Laboratory of Ophthalmology (No:2012PI05) （No:2012PI05）
Five Five Cultivation Project of Ophthalmic Center,Sun Yat-Sen University （）
