疑难病杂志2017，Vol.16Issue(5)：525-529,5.DOI:10.3969/j.issn.1671-6450.2017.05.024
Toll样受体通过炎性反应和免疫反应介导心肌纤维化的研究进展
The research advancement of TLR in myocardial fibrosis by inflammation and immune response
摘要
Abstract
Toll-like receptors (TLRs) are important receptors that mediate innate immune responses, have type I transmembrane proteins and recognize large amounts of exogenous ligands. Studies have shown that TLRs are not only resistant to pathogenic microbial invasion, but also in myocardial ischemia and reperfusion injury, atherosclerosis, hypertension and other non-infectious lesions-mediated myocardial fibrosis plays a very important role. In this paper, we discuss the possible mechanism of TLR4, especially TLR4, in myocardial fibrosis, and hope that we can further elucidate the potential mechanism of myocardial fibrosis. At the same time, the prevention of muscle fibrosis provides a new perspective.关键词
Toll样受体/心肌纤维化/炎性反应/免疫反应Key words
Toll like receptor/Myocardial fibrosis/Inflammation response/Immune response引用本文复制引用
吴限..Toll样受体通过炎性反应和免疫反应介导心肌纤维化的研究进展[J].疑难病杂志,2017,16(5):525-529,5.基金项目
国家自然科学基金资助项目(81170085) （81170085）
