湖北医药学院学报2016，Vol.35Issue(4)：366-370,5.DOI:10.13819/j.issn.1006-9674.2016.04.008
三种抗病毒方案治疗失代偿期乙型肝炎肝硬化的疗效观察
Therapeutic Effects of Three Kinds of Antiviral Regimens on Treatment of Patients with HBV Related Decompensated Cirrhosis
占国清 1李芳 1李儒贵 1刘翔 1郭鹏 1张薇薇 1谭华炳1
作者信息
- 1. 湖北医药学院附属人民医院感染性疾病科,湖北十堰442000
- 折叠
摘要
Abstract
Objective To compare the clinical effects of three kinds of antiviral regimens with telbivudine,entecavir or lamivudine combined with adefovir in patients with HBV related decompensated cirrhosis.Methods The clinical data of 85 patients with hepatitis B-induced decompensated liver cirrhosis hospitalized in our hospital from January 2009 to January 2012 were retrospectively analyzed.The patients were divided into telbivudine (LdT) group (n =29),entecavir(ETV) group (n =30) and lamivudine combined with adefovir(LAM & ADV) group (n =26)according to the different antiviral regimens.After treating for more than 96 weeks,the recovery rates of alanine aminotransferase(ALT) and negative rate of HBV DNA at 12,24 and 96 week,the negative rate and the conversion rate of hepatitis B e antigen(HBeAg),the rate of drug resistance and Child-Pugh grading changes at 96 week were compared among three groups.Results All patients were treated with antiviral therapy for more than 96 weeks.The differences of the recovery rates of ALT and negative rate of HBV DNA had no significant difference among three groups at 12,24 and 96 week.The negative rate of HBeAg was 42.9％ in LdT group,which was significantly higher than 22.7％ in ETV group and 20.0％ in LAM & ADV group,the conversion rate of HBeAg in the LdT group was 28.6％,which was significantly higher than 22.7％ in ETV group and 20.0％ in LAM & ADV group,but the differences among three groups had no significance (P =0.216,0.415,respectively).There was no significant difference in drug resistance among the three groups.After treatment,Child-Pugh gradings of the three groups were significanctly improved than each of them before treatment,but which had no significant difference among the three groups after treatment.Conclusion The three kinds of antiviral regimens could effectively inhibit HBV DNA replication and improve liver function in the treatment of HBV related decompensated cirrhosis,the telbivudine group may be better in improving HBeAg negative rate and conversion rate than the other two groups,but the other clinical efficacy of the three groups were similar.关键词
失代偿期肝硬化/肝炎,乙型,慢性/抗病毒/疗效Key words
Decompensated cirrhosis/Chronic hepatitis B/Antiviral/Efficacy引用本文复制引用
占国清,李芳,李儒贵,刘翔,郭鹏,张薇薇,谭华炳..三种抗病毒方案治疗失代偿期乙型肝炎肝硬化的疗效观察[J].湖北医药学院学报,2016,35(4):366-370,5.
