湖北医药学院学报2016，Vol.35Issue(4)：371-373,3.DOI:10.13819/j.issn.1006-9674.2016.04.009
正畸诱导的炎性牙根吸收动物模型的改良
Modification of Rat Model with Inflammatory Root Resorption Induced by Orthodontic
摘要
Abstract
Objective To explore an effective method to build an inflammatory root resorption animal model in rats induced by orthodontic for the mechanism research.Methods Total 32 SD rats aged 8 weeks were randomly divided into conventional group and modified group(n=16).A force of 100 g was applied to move the right upper first molars mesially in rats of conventional group(not trim the lower incisors)and modified group(trim the lower incisors).The situation of devices loose off and resorption lacunae were observed in the two groups.And forced for 7 days,EDTA was used for decalcification of maxillae with molars,then the change of histology was observed.Results After forced for 7 days,the devices were all loosen off,the palatine root surface of upper right side first molar was smooth and no resorption lacunae in conventional group.While in modification group,there were observed that no devices was loosen off,resorption lacunae in the palatine root surface and multinucleated osteoclast in peridental membrane.Conclusion The rat model with inflammatory root resorption induced by orthodontic could be successfully established by cutting the lower incisor and applying continuous heavy force.关键词
正畸诱导的炎症性牙根吸收/动物模型/大鼠Key words
Inflammatory root resorption induced by orthodontic/Animal model/Rat引用本文复制引用
胡亚军,刘文韬,徐小明,陈睿..正畸诱导的炎性牙根吸收动物模型的改良[J].湖北医药学院学报,2016,35(4):371-373,3.基金项目
湖北医药学院校级基金(2012043) （2012043）
