湖北医药学院学报2016，Vol.35Issue(6)：547-552,556,7.DOI:10.13819/j.issn.1006-9674.2016.06.005
布拉氏酵母菌对儿童抗生素相关性腹泻预防与治疗的Meta分析
Probiotics for Prevention and Treatment of Antibiotic-Associated Diarrhea in Children: a Meta-analysis
摘要
Abstract
Objective To systematically review the efficacy and safety of Saccharomyces boulardiifor the prevention and treatment of antibiotic-associated diarrhea (AAD) in children.Methods We electronically searched PubMed,EMbase,CENTRAL,CNKI,WanFang Data,CBM and VIP databases to collect randomized controlled trials (RCTs) about Saccharomyces boulardii for the prevention and treatment of AAD in children from inception to August 2016.Two reviewers independently screened the literatures according to the inclusion and exclusion criteria,extracted data,evaluated the quality and cross-checked.Then a meta-analysis was performed by using R software.Results;A total of 12 RCTs were included,involving 2 750 children.The results of meta-analysis showed that the Saccharomyces boulardii group had a lower incidence of AAD in comparison with control group [Risk ratio(RR)=0.54(95％CI=0.47～0.61,P＜0.0001)].Saccharomyces boulardii also reduced the disease course of AAD and duration of hospitalization,their standardised mean difference were 1.17(95％CI =-1.48～-0.87,P＜0.0001) and-2.32(95％CI =-4.05 ～-0.60,P＜0.0001),respectively.Conclusion The pooled evidences found that Saccharomyces boulardii are associated with a reduction in AAD and duration of hospitalization in Children.Due to the heterogeneity of the included studies,more research is needed to verify the above conclusions.关键词
抗生素相关性腹泻/布拉氏酵母菌/儿童/Meta分析/随机对照试验Key words
Antibiotic-associated diarrhea/Saccharomyces boulardii/Children/Meta-analysis/Randomized controlled引用本文复制引用
周华,姜源渊,吴斌,吉山宝..布拉氏酵母菌对儿童抗生素相关性腹泻预防与治疗的Meta分析[J].湖北医药学院学报,2016,35(6):547-552,556,7.基金项目
上海市卫计委“第四轮公共卫生三年行动计划重点学科建设计划--循证公共卫生与卫生经济学”(15GWZK0901) （15GWZK0901）
