诊断学理论与实践2017，Vol.16Issue(2)：166-170,5.DOI:10.16150/j.1671-2870.2017.02.009
进展期胃癌人表皮生长因子受体2蛋白表达与临床病理学特征的关系
Relationship between HER2 expression and clinicopathological features in advanced gastric cancer
乔长婷 1李蕾 1邬安妮 1袁菲1
作者信息
- 1. 上海交通大学医学院附属瑞金医院病理科,上海 200025
- 折叠
摘要
Abstract
Objective:To investigate the expression of human epidermal growth factor receptor-2 (HER2) in ad-vanced gastric cancer and the correlation between HER2 expression and clinicopathological features. Methods: A total of 542 consecutive patients with gastric cancer from 2011 to 2015 were enrolled, and all the patients received resection of the tumor at Ruijin Hospital. HER2 expression in tumor tissue was detected by immunohistochemistry in accordance with the Hoffmann scoring system. Correlation between HER2 expression and clinicopathological features was statistically ana-lyzed. Results:One hundred and forty-one cases (26%) were scored as strongly positive for HER2 membrane staining (3+). HER2 positivity was statistically associated with local invasion (P=0.002), lymph node metastasis (P<0.001), and TNM staging (P=0.030), respectively. HER2 overexpression was more frequently detected in intestinal (30.5%) than that in dif-fuse (16.1%) type of tumor according to Lauren's classification. Similarly, HER2 overexpression was more frequently de-tected in well or moderate differentiated (43.0%) than in poor or undifferentiated (22.8%) tumor according to WHO classi-fication. Conclusions: An accurate standardized scoring system for HER2 expression in gastric cancer patients is impor-tant for selecting patients for trastuzumab treatment. This study indicates that patients with intestinal type, well differen-tiated and late staging hare a high rate of HER2 expression, and they were the candidates for targeted therapy using trastuzumab.关键词
人表皮生长因子受体2/胃癌/临床病理学特征/免疫组织化学染色Key words
Human epidermal growth factor receptor-2/Gastric cancer/Clinicopathological characteristics/Immuno-histochemistry分类
医药卫生引用本文复制引用
乔长婷,李蕾,邬安妮,袁菲..进展期胃癌人表皮生长因子受体2蛋白表达与临床病理学特征的关系[J].诊断学理论与实践,2017,16(2):166-170,5.
