诊断学理论与实践2017，Vol.16Issue(2)：195-198,4.DOI:10.16150/j.1671-2870.2017.02.014
p16与Ki-67含量检测在子宫颈上皮内病变临床诊断中的意义
Significance of detection of p16 and Ki-67 in diagnosis of cervical intraepithelial lesions
刘镜文 1吴秋良2
作者信息
- 1. 广东省惠州市第一妇幼保健院病理科,广东 惠州 516211
- 2. 广东省广州市中山大学肿瘤防治中心病理科,广东 广州 510060
- 折叠
摘要
Abstract
Objective:To assess the value of detection of p16 and Ki-67 in diagnosis of cervical intraepithelial le-sions for providing a basis for its clinical application. Methods:Two hundred cases of cervical intraepithelial lesion selec-ted from January 2015 to June 2016 were served as the object of this study. The biopsy paraffin sections after appropriate antigen retrieval were used for detection of p16 and Ki-67 immunohistochemically and the value of detection of p16 and Ki-67 in diagnosis of cervical intraepithelial lesion was analyzed. Results: The positive expression rates of p16 and Ki-67 in cervical squamous intraepithelial lesion (SIL) were significantly higher than those in atrophic cervix and cervical squa-mous epithelial metaplasia (P<0.05). The positive expression rates of p16 and Ki-67 in high grade squamous intraepithelial lesion (HSIL) were significantly higher than those in low grade squamous intraepithelial lesion (LSIL) (P<0.05). In cervical intraepithelial lesion, the expressions of p16 and Ki-67 were in good consistency, and was statistically significant (P<0.05). The p16, Ki67 positive cells extended to 2/3 layer or whole layer in HSIL, and the positive expression rate was signifi-cantly higher than that in LSIL (P<0.05). Conclusions:Detection of p16 and Ki-67 can be used as an important indicator for cervical intraepithelial lesion and has high diagnostic value clinically.关键词
p16/Ki-67/宫颈上皮内病变/临床诊断Key words
p16/Ki-67/Cervical intraepithelial lesion/Clinical diagnosis分类
医药卫生引用本文复制引用
刘镜文,吴秋良..p16与Ki-67含量检测在子宫颈上皮内病变临床诊断中的意义[J].诊断学理论与实践,2017,16(2):195-198,4.
