中风与神经疾病杂志2017，Vol.34Issue(4)：328-331,4.
海人藻酸致急慢性癫痫模型中Nrf2的变化及其对神经元的影响
Expression of Nrf2 on epileptic rat model induced by kianic acid and effect on neuron
摘要
Abstract
Objective To investigate the expression of Nrf2 in epileptic rat model induced by kianic acid and its effect on neuron.Methods Rats were injected kianic acid (1 μg/μl)1.0 μl into hippocampal,and divided randomly into model 24 h (acute model group),model 28 d (chronic model group),sham group were inject equal volume saline,10 for each group.We observed the change of neuron by using Nissl staining;Immunohistochemistry and Western blotting were to measure the expression of Nrf2.Results Compared with sham,the results of Nissl staining suggested that Nissl bodies in nervous cells decreased in model 24 h group and model 28 d group,and especially in model 28 d group;the results of Immunohistochemistry and Western blotting demonstrated that the expression of Nrf2 increased in model 24 h group,decreased in model 28 d group.Conclusion Nrf2 had possible neuroprotective effect in acute kianic acid model and the mechanism was probably related to the upregulation the expression of Nrf2.关键词
癫痫/海人藻酸/Nrf2Key words
Epilepsy/Kianic acid/Nrf2分类
临床医学引用本文复制引用
齐越,向绍杰,姜鸿,李纪彤,秦文艳,刘小虎,韦丹,张冰冰,贾冬..海人藻酸致急慢性癫痫模型中Nrf2的变化及其对神经元的影响[J].中风与神经疾病杂志,2017,34(4):328-331,4.基金项目
国家科技部"十二五""重大新药创制"专项课题(2012ZX09102201-005) （2012ZX09102201-005）
辽宁省科技厅基金资助项目(2004226010-6) （2004226010-6）
