摘要
Abstract
Objective To analyze the relationship between carotid artery intima-media thickness (IMT) and the level of serum Adropin in patients with cerebral infarction (CI),and explore the predictive value of serum Adropin in the evaluation of atherosclerosis.Methods A total of 84 patients with CI were enrolled in the study.Carotid IMT was measured by color doppler ultrasonography.According to IMT,patients with CI were divided to 3 groups:normal IMT group (n=20),IMT thicknessing group (n=38) and plaque formation group (n=26).Adropin level was measured from blood serum samples using ELISA.The correlation between carotid IMT and the level of serum Adropin was analyzed.Results The level of serum Adropin in IMT normal group were significantly higher than that in IMT thicknessing group and plaque formation group (all P<0.01).The level of serum Adropin in IMT thicknessing group were significantly higher than that in IMT plaque formation group (P<0.01).Correlation analyses showed that there were positive correlation between IMT and Age (r=0.342,P=0.001),SBP (r=0.536,P=0.000),LDL-C (r=0.285,P=0.009),UA (r=0.282,P=0.009).There was a negative correlation between IMT and serum Adropin (r=-0.500,P=0.000).Logistic regression analysis showed that Age,SBP,UA,LDL-C,declined Adropin were the independent risk factors of carotid atherosclerosis.Conclusion The level of serum Adropin decreased along with the degree of carotid atherosclerosis.To a certain extent,Adropin can reflect the severity of carotid atherosclerosis.关键词
Adropin/脑梗死/动脉粥样硬化/颈动脉内中膜厚度Key words
Adropin/Cerebral infarction/Atherosclerosis/Carotid artery intima-media thickness分类
医药卫生
