CD64在儿童肺部感染诊断中的临床意义OA

Objective To evaluate the diagnosis and treatment value of changes in the level of peripheral blood neutrophil CD64 in pulmonary infection children.Methods The levels of peripheral blood neutrophil CD64 were measured by using flow cytometry and C reactive protein (CRP), WBC count and bacterial culture results were carried out comparing.According to the clinical manifestationsand laboratory test results the patients were divided into bacterial pneumonia (n=20, the bacterial culture positive)and Mycoplasma pneumonia infection group(n=20, Mycoplasma IgM antibody positive).Twenty healthy children with non-infection disease were enrolled as controls.Results The expression level of neutrophil CD64 was found in each group had statistical significance by using pairwise comparison.The expression level of CRP in the bacterial pneumonia group were significantly higher than those in The expression level of the control group and CRP in Mycoplasma pneumonia infection group were significantly higher than those in the bacterial pneumonia group.WBC count in the bacterial pneumonia group were significantly higher than those in The expression level of the control group and WBC count in Mycoplasma pneumonia infection group were significantly higher than those in control group.Conclusions The elevated level of CD64 is a sensitive and specific indicator for diagnosing bacterial pneumonia and helpful in the early diagnosis of pulmonary bacterial infection.