中国病理生理杂志Issue(4)：754-757,4.DOI:10.3969/j.issn.1000-4718.2017.04.030
基于癌症基因图集数据库与免疫组织化学方法分析SMARCB1对肝细胞癌早期诊断及预后的作用
Effect of SMARCB1 on early diagnosis and prognosis of hepatocellular carcinoma
摘要
Abstract
AIM: To illuminate the effect of SWI/SNF-related, matrix-associated, actin-dependent regulator of chromatin, subfamily b, member 1 (SMARCB1) in early diagnosis and prognosis of hepatocellular carcinoma (HCC) by determining the clinical expression of SMARCB1 in HCC tissue and benign liver tissue.METHODS: The specific target gene SMARCB1 was selected from these genes by using The Cancer Genome Atlas (TCGA).SMARCB1 expression in HCC tissue and benign liver tissue was measured by immunohistochemistry.Further statistical analysis of TCGA was performed to illuminate the role of SMARCB1 on HCC occurrence and progression.RESULTS: Compared with the benign liver tissue, immunohistochemical staining showed that SMARCB1 expression was significantly up-regulated in the HCC tissue (P<0.01).In addition, SMARCB1 expression was significantly associated with advanced tumor stage (P<0.05).The relation between SMARCB1 expression at mRNA level and clinical prognosis was analyzed.The results indicated that high SMARCB1 expression was an independent prognostic factor for HCC (P<0.05).CONCLUSION: SMARCB1 may play a part as a carcinogenic gene in tumorigenesis.We can distinguish primary HCC samples from non-malignant samples according to its different clinical expression.High SMARCB1 expression probably predicts poor outcome in HCC patients.关键词
肝细胞癌/SMARCB1/诊断/预后Key words
Hepatocellular carcinoma/SMARCB1/Diagnosis/Prognosis分类
医药卫生引用本文复制引用
王健,曹天生,张升敏,吴佳勉,卢卓才,杨建荣,巫泓生,陈浩,林波,许荣华..基于癌症基因图集数据库与免疫组织化学方法分析SMARCB1对肝细胞癌早期诊断及预后的作用[J].中国病理生理杂志,2017,(4):754-757,4.基金项目
海南省自然科学基金资助项目(No.ZDXM2015080 （）
No.309063) （）
广州市花都区科技和信息化局项目(No.15-HDWS-012) （No.15-HDWS-012）
